Most Read Articles
12 May 2016

A study published in Science shows new strains of microbes from the donor were more likely to colonize the patient’s intestines if that particular species exists in the patient’s gut.

Rachel Soon, 18 Jan 2017

Patients infected with Helicobacter pylori strains derived from different geographical human ancestries than their own are likely to develop more severe symptoms which include gastric cancers, says an expert.

Jairia Dela Cruz, 19 Oct 2017
Having both type 1 diabetes and coeliac disease (CD) autoimmunity in early childhood appears to be more common than expected, with the development of islet autoantibodies (IAs) conferring a significant risk of subsequent tissue transglutaminase autoantibodies (tTGAs), according to data from the TEDDY* study.
Pank Jit Sin, 25 Nov 2015
The many species of bacteria living in the human gut compete with each other to keep their human host healthy, scientists suggest. 

Complete endoscopic resection may not be suitable as sole therapy for Barrett’s oesophagus

13 Feb 2018

Complete endoscopic resection (CER) of Barrett’s oesophagus (BE) results in a complete eradication rate of 85 percent, with nearly 6-percent recurrent rate of neoplasia, reports a recent study. Additionally, the estimated rate of postprocedural stricture was 37.4 percent.

A total of eight studies involving 676 patients (high-grade dysplasia, 54 percent) met the inclusion criteria.

The pooled estimated rates were 85.0 percent (95 percent CI, 79.4‒89.2 percent) for complete eradication of intestinal metaplasia and 96.6 percent (94.0‒98.1 percent) for complete eradication of intestinal neoplasia. Recurrence rates of intestinal metaplasia and neoplasia were 15.7 percent (8.0‒28.4 percent) and 5.8 percent (3.9‒8.6 percent), respectively.

Estimated incidences of adverse events were as follows: stricture (37.4 percent; 24.4‒52.6 percent), bleeding (7.9 percent; 4.4‒13.8 percent) and perforation (2.3 percent; 1.3‒4.1 percent).

“On the basis of this high rate of adverse events and significant heterogeneity in the studies included, the present meta-analysis cannot endorse CER as sole therapy for BE,” the investigators said.

To report the rate of eradication and recurrence of both neoplasia and intestinal mucosa, as well as the rate of adverse events for CER of BE, the investigators conducted a systematic review and meta-analysis of cohort studies that reported the clinical outcome of patients with BE who underwent CER and had at least 15-month follow-up after the time of elimination of BE.

Main outcomes included pooled estimated rates of complete eradication of intestinal metaplasia and neoplasia, recurrence of intestinal metaplasia and neoplasia, and incidence of oesophageal stricture, bleeding and perforation.

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Most Read Articles
12 May 2016

A study published in Science shows new strains of microbes from the donor were more likely to colonize the patient’s intestines if that particular species exists in the patient’s gut.

Rachel Soon, 18 Jan 2017

Patients infected with Helicobacter pylori strains derived from different geographical human ancestries than their own are likely to develop more severe symptoms which include gastric cancers, says an expert.

Jairia Dela Cruz, 19 Oct 2017
Having both type 1 diabetes and coeliac disease (CD) autoimmunity in early childhood appears to be more common than expected, with the development of islet autoantibodies (IAs) conferring a significant risk of subsequent tissue transglutaminase autoantibodies (tTGAs), according to data from the TEDDY* study.
Pank Jit Sin, 25 Nov 2015
The many species of bacteria living in the human gut compete with each other to keep their human host healthy, scientists suggest.