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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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Comorbidity type affects quality of life in PsA patients

02 Apr 2020

The type of comorbidity, rather than its number, appears to have a greater impact on the quality of life (QoL) of patients with psoriatic arthritis (PsA), a recent study has found.

For instance, anxiety in PsA independently correlates with QoL and may be a significant factor to consider in daily clinical practice, according to the researchers.

This analysis included patients from a multicentric, cross-sectional study on comorbidities in PsA. The researchers collected data on patient comorbidities and subsequently used these to compute the modified Rheumatic Disease Comorbidity Index (mRDCI). QoL was gauged using the Medical Outcomes Study Short Form-36 questionnaire physical (PCS) and mental component summary (MCS) scales.

A total of 124 patients (mean age, 52.6±12.6 years) met the Classification for Psoriatic Arthritis criteria (CASPAR), of whom 62.1 percent were male. Median disease duration was 11.3±9.6 years. On average, patients had 2.0±1.3 comorbid conditions, while 30.6 percent have currently or a history of 3 comorbidities.

Multivariable linear regression analysis revealed that only anxiety was significantly associated with mental health (p<0.0001), accounting for 28.7 percent of the variance in MCS scores. In addition, MCS significantly correlated with the mRDCI score, which explained 4.9 percent of the variance in MCS (β, –1.56; R2, 0.049; p=0.0167). On the other hand, PCS had a significant correlation with neither type nor number of comorbidities.

“In PsA, comorbidities add to the burden of disease, which may lead to poorer quality of life,” the researchers said.

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Most Read Articles
4 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.