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Comorbidities worsen HRQoL after surgery in patients with differentiated thyroid carcinoma

16 Apr 2020

Patients with differentiated thyroid carcinoma (DTC) who had undergone thyroidectomy suffer from poorer health-related quality of life (HRQoL), which may be exacerbated by comorbidities, a recent study has found.

The study included 174 DTC patients who underwent thyroidectomy and 174 matched controls. The 36-item Short Form (SF-36) survey was used to measure HRQoL, and structured questionnaires were used to collect sociodemographic and comorbidity information.

At the 1-year follow-up, DTC patients scored significantly lower on almost all domains of the SF-36 questionnaire. Role-physical (79.5±31.0 vs 86.6±23.8; p=0.016), bodily pain (79.7±23.1 vs 87.1±17.7; p<0.001), general health (61.4±25.3 vs 73.1±22.1; p<0.001) and vitality (62.1±26.7 vs 70.8±22.3; p<0.001) were all significantly worse in DTC patients.

The same was true for social functioning (77.2±17.3 vs 84.8±13.2; p<0.001), role-emotional (74.3±23.6 vs 84.3±22.2; p<0.001), mental health (71.5±21.8 vs 81.7±20.3; p<0.001), and in the physical (PCS; 76.8±10.5 vs 83.3±9.9; p<0.001) and mental (MCS; 71.3±10.8 vs 80.4±10.1; p<0.001) component summaries.

Only physical functioning was comparable between patients and controls (p=0.694).

The presence of one or more comorbidities appeared to worsen SF-36 scores, resulting in significantly lower physical functioning (p<0.001). This trend was consistent across all domains of SF-36, except for social functioning, which was only significantly decreased by having at least two comorbidities (p<0.001).

This was further confirmed through multivariate analysis, which found that hypertension, diabetes and depression all correlated significantly with poor PCS scores, while hypertension, asthma and depression predicted lower MCS scores after 1 year.

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Most Read Articles
5 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 7 hours ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

2 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, Yesterday
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.