Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
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Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.

Comorbidities associated with hand OA disease burden

30 Nov 2017

There are significant associations between comorbidities and hand osteoarthritis (OA) disease burden, a recent study has found.

The authors used cross-sectional data from the Hand Osteoarthritis in Secondary Care (HOSTAS) cohort, including consecutive patients with primary hand OA. A total of 19 comorbidities were evaluated: 18 self-reported (modified Charlson index and osteoporosis) and obesity (body mass index ≥30 kg/m2).

Adjusting for age and sex, mean differences were estimated between patients with vs without comorbidities for the following: general disease burden (health-related quality of life [HRQoL], Medical Outcomes Study Short Form-36 physical component scale [0 to 100]) and disease-specific burden (self-reported hand function [0 to 36], pain [0 to 20; Australian/Canadian Hand OA Index) and tender joint count (TJC; 0 to 30). Those considered clinically relevant were differences above a minimal clinically important improvement.

Overall, 538 patients (mean age 61 years; 86 percent women; 88 percent met the American College of Rheumatology classification criteria) were included in the analysis. Mean HRQoL, function, pain and TJC were 44.7, 15.6, 9.3 and 4.8, respectively.

More than half of the patients (54 percent) had any comorbidity, which was unfavourable (adjusted mean difference presence/absence any comorbidity: HRQoL, ‒4.4; 95 percent CI, ‒5.8 to ‒3.0; function, 1.9; 0.4 to 3.3; pain, 1.4; 0.6 to 2.1; TJC, 1.3; 0.4 to 2.2).

Number of comorbidities, as well as musculoskeletal (eg, connective tissue disease) and nonmusculoskeletal comorbidities (eg, pulmonary and cardiovascular disease), correlated with disease burden. There were also clinically relevant associations with HRQoL and function.

These findings show that “the role of comorbidities in hand OA should be considered when interpreting disease outcomes and in patient management,” according to the authors.

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Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.