Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
Tristan Manalac, 08 Jul 2020
Elderly coronavirus disease 2019 (COVID-19) patients with high nutritional risk appear to suffer worse outcomes, such as longer hospital stay and greater disease severity, according to a recent study.
01 Jan 2019
Twice-daily administration of a combined Lactobacillus rhamnosus and Lactobacillus helveticus probiotic in children with suspected gastroenteritis fails to prevent the development of moderate-to-severe gastroenteritis within 2 weeks after presentation, as shown in a recent study.
25 Oct 2018
Human papillomaviruses (HPVs) are commonly found in the oral cavity, but it does not appear that oral HPVs contribute to an increased risk of oesophageal cancer, according to a study.

Comorbidities a risk factor for severe SARS-CoV-2 infection

29 May 2020

Individuals with comorbidities such as hypertension and respiratory system and cardiovascular diseases may have a greater susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a study suggests.

Researchers conducted a systematic review and meta-analysis to assess the prevalence of comorbidities and the risk of underlying diseases in patients with severe vs nonsevere SARS-CoV-2 infection.

The meta-analysis included seven studies involving 1,576 infected patients (median age, 49.6 years; 56.5 percent male). Pooled data revealed fever (91.3 percent) to be the most prevalent clinical symptom, followed by cough (67.7 percent), fatigue (51.0 percent), and dyspnoea (30.4 percent). There was significant heterogeneity observed (I2, 84.9–96.4 percent; p=0.000). 

In terms of comorbidities, the most prevalent was hypertension (21.1 percent) and diabetes (9.7 percent), followed by cardiovascular (8.4 percent) and respiratory system (1.5 percent) diseases. There were significant heterogeneities seen for estimates of hypertension and cardiovascular disease (p=0.000) but not for diabetes (p=0.209) and respiratory system disease (p=0.872), with I2 indices ranging from 0 percent to 86.2 percent.

Compared with nonsevere infection, severe SARS-CoV-2 was associated with a higher likelihood of having hypertension (odds ratio [OR], 2.36, 95 percent confidence interval [CI], 1.46–3.83), respiratory system disease (OR, 2.46, 95 percent CI, 1.76–3.44), and cardiovascular disease (OR, 3.42, 95 percent CI, 1.88–6.22). Estimates showed low heterogeneity (I2, 0–39.3 percent).

Despite a need for more adequately powered studies to validate the observed association, the findings highlight the importance of adopting targeted public health vaccination interventions to better protect people with chronic diseases from infection with SARS-CoV-2 and other respiratory viruses, given the increasing prevalence of chronic diseases, according to the researchers.

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Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
Tristan Manalac, 08 Jul 2020
Elderly coronavirus disease 2019 (COVID-19) patients with high nutritional risk appear to suffer worse outcomes, such as longer hospital stay and greater disease severity, according to a recent study.
01 Jan 2019
Twice-daily administration of a combined Lactobacillus rhamnosus and Lactobacillus helveticus probiotic in children with suspected gastroenteritis fails to prevent the development of moderate-to-severe gastroenteritis within 2 weeks after presentation, as shown in a recent study.
25 Oct 2018
Human papillomaviruses (HPVs) are commonly found in the oral cavity, but it does not appear that oral HPVs contribute to an increased risk of oesophageal cancer, according to a study.