Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Comorbidities, disease severity predict death in hospitalized asthma patients

18 Apr 2020

The risk of death in patients hospitalized for asthma exacerbation is associated with specific comorbidities, disease severity, and prescription patterns of short-acting β2-agonist (SABA), oral (OCS) and inhaled corticosteroids (ICS), according to a study.

The analysis involved 267 patients who died after asthma admission and 1,035 controls who were discharged after admission. The median age of the overall population was 77 years, and 50.7 percent of the patients were female. The mean duration of follow-up was 3 years.

In multivariable conditional logistic regression models, independent risk factors for death included comorbidities of pneumonia (adjusted odds ratio [aOR], 3.82, 95 percent confidence interval [CI], 2.41–6.05), genitourinary disease (aOR, 1.75, 95 percent CI, 1.17–2.62), septicemia (aOR, 4.26, 95 percent CI, 2.61–6.94), diabetes mellitus (aOR, 2.10, 95 percent CI, 1.30–3.38), arrhythmia (aOR, 2.00, 95 percent CI, 1.14–3.50), and a history of asthmatic hospitalization (aOR, 4.48, 95 percent CI, 2.77–7.25).

The risk of death also increased with the use of SABA and OCS use at >70 mg prednisolone during previous hospitalization (p<0.05) and OCS use at ≥110 mg prednisolone/month during outpatient treatment (aOR, 2.21, 95 percent CI, 1.08–4.50).

On the other hand, ICS use of ≥4 canisters/year conferred a survival benefit (aOR, 0.39, 95 percent CI, 0.19–0.78).

The present data may aid in identifying asthmatic patients who are at a higher mortality risk as well as refining the management of the condition, researchers said.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.