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01 Oct 2020
In patients with major depressive disorder being treated with antidepressants, zinc supplementation contributes to a substantial reduction in depressive symptoms, a study has found.

Comorbid mental, physical disorders climb among SG adults

Stephen Padilla
16 Oct 2020

Singapore has seen an increase in the prevalence of comorbid mental and physical disorders between 2010 and 2016, according to a study.

“After controlling for all sociodemographic factors in multinomial logistic regression, we found that the prevalence remained significantly higher, suggesting that the increase was not influenced by population growth or changing demographics,” the researchers said.

Data from two repeated nationally representative cross-sectional survey conducted among residents aged ≥18 years in Singapore were extracted. Pooled multinomial logistic regression analyses were performed to test significant changes.

The analyses revealed a significant increase in the prevalence of comorbid mental and physical disorders from 5.8 percent in 2010 to 6.7 percent in 2016. [Singapore Med J 2020;doi:10.11622/smedj.2020124]

Significant increases over time were observed among those with physical disorders in the prevalence of comorbid generalized anxiety disorder (GAD; 0.1 percent vs 0.4 percent) and obsessive-compulsive disorder (OCD; 1.4 percent vs 3.9 percent) in diabetes mellitus, as well as alcohol dependence in cardiovascular disorders (0.1 percent vs 1.3 percent).

Among those with mental disorders, significant increases over time were noted in the prevalence of comorbid diabetes mellitus in OCD (4.1 percent vs 10.9 percent), cancer in major depressive disorder (0.4 percent vs 2.4 percent), and cardiovascular disorders in GAD (0.4 percent vs 6.7 percent) and alcohol dependence (0.9 percent vs 11.8 percent).

There were also significant changes in the overall prevalence of comorbid mental and physical disorders across age group, education, and employment status.

These findings were consistent with those of cohort studies in the UK between 2000 and 2014 and in the Netherlands between 1995 and 2010, which reported an increase in the prevalence of comorbidity among patients with cardiovascular disease and colorectal cancer over time. [PLoS Med 2018;15:e1002513; Int J Cancer 2013;132:2157-2163]

Such findings also support the “need for more appropriate clinical management with better integration between mental health and general medical care professionals across all aspects of the healthcare system to treat comorbidity in Singapore,” the researchers said.

In addition, earlier studies suggested that changes in lifestyle factors, such as increased smoking, low physical activity, heavy alcohol use, and unhealthy diet, over the years could have led to the significant change in comorbidity. [BMC Public Health 2014;14:686; BMC Public Health 2012;12:201; Psychiatry Investig 2018;15:246-253]

In Singapore, noncommunicable disease was the most common disease burden among young people when they reach late childhood, adolescence and adulthood. Mental disorder, which is a noncommunicable disease, represented the largest contributor to disease burden for Singaporeans aged 10–34 years, with diet, tobacco, and high blood pressure being the leading risk factors. [www.healthdata.org/sites/default/files/files/policy_report/2019/GBD_2017_Singapore_Report.pdf]

“Hence, these findings suggest that the increase in comorbidity of mental and physical disorders among the younger population might be associated with changes in behavioural factors, as well as an increasing prevalence of mental disorders in this group,” the researchers said.

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Most Read Articles
01 Oct 2020
In patients with major depressive disorder being treated with antidepressants, zinc supplementation contributes to a substantial reduction in depressive symptoms, a study has found.