Most Read Articles
5 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.

Common features, outcomes of CD complicated by upper gastrointestinal tract strictures

03 Nov 2020
Crohn’s is not the end of the world, as Kathleen Baker’s silver medal proves

Most of the upper gastrointestinal tract (UGT) strictures complicating Crohn’s disease (CD) occur in the duodenum and require surgical treatment, a recent study has found.

Researchers conducted a retrospective multicentre study on 60 CD patients (median age at stricture diagnosis, 31.0 years; 33 percent female) with UGT strictures. The primary outcome measure was surgery-free survival. The effects of other medical and endoscopic interventions were also assessed, and predictors of surgery were identified.

Sixty percent (n=36) of the participants had their UGT strictures in the duodenum, while an additional 10 percent and 1 percent had the stricture in the stomach and duodenum, and in the duodenum and jejunum, respectively. Other common sites were the proximal jejunum and oesophagus.

Over a median follow-up of 5.5 years, 45 percent of the participants underwent surgery. Common reasons were gastro-entero-anastomosis (n=14) and duodeno-jejunal restrictions (n=8). In the same time interval, 77 endoscopic procedures were performed in 30 participants, and 70 medical treatments were given to 51 patients. One patient died.

The calculated rate of surgery-free survival at 1 year was 75 percent, which dropped to 64 percent at 5 years. At the end of the follow-up, medical and/or endoscopic treatment helped 55 percent (n=33) of the participants to avoid surgery.

Multivariate logistic regression analysis identified the use of antitumour necrosis factors, either alone (odds ratio [OR], 0.2, 95 percent confidence interval [CI], 0.04–0.9; p=0.03) or in combination with an immunosuppressant (OR, 0.2, 95 percent CI, 0.05–0.9; p=0.03), as a significant protective factor against surgery.

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Most Read Articles
5 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
6 days ago
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.