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Stephen Padilla, 24 Jun 2019
Two independent, phase III studies (PERFECT 1 and 2) have shown the efficacy and safety of trifarotene 50-μg/g cream in the treatment of moderate acne on the face and trunk.

Common comorbidities in rosacea patients

23 May 2019

A lot of rosacea patients are obese and have longer exposure to sun, a study reports. Depending on rosacea severity, patients may also have neurological, psychiatric and gastrointestinal, or metabolic and cardiovascular system disorders.

Researchers looked into 1,195 rosacea patients and 621 controls without rosacea aged 18–85 years. They documented the principal rosacea subtype, physician global assessment of severity and duration of rosacea.

Data on patients’ demographics, clinical findings and lifestyle data were obtained using a structured physician‐administered questionnaire. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any such comorbidity, and the use of medications to treat any comorbidities.

In the rosacea group (median duration, 3 years), 56.2 percent of patients had the erythematotelangiectatic subtype, 37.7 percent had papulopustular, 5.3 percent had phymatous, and 0.9 percent had ocular. Rosacea severity was mild in 31.0 percent patients, moderate in 49.4 percent and severe in 19.6 percent.

Compared with controls, rosacea patients had a significantly higher probability of having respiratory tract, gastrointestinal system, and metabolic and hepatobiliary system disorders (p<0.05 for all). There were significant associations between mild-to-moderate disease and neurological disorders (especially migraine), between moderate disease and psychiatric (especially major depression) and gastrointestinal system disorders, and between severe disease and metabolic and cardiovascular system disorders.

The findings indicate that clinicians must assess rosacea patients in terms of systemic comorbidities, with the importance of such assessment increasing as the duration and severity of rosacea increase, researchers said.

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Most Read Articles
Stephen Padilla, 24 Jun 2019
Two independent, phase III studies (PERFECT 1 and 2) have shown the efficacy and safety of trifarotene 50-μg/g cream in the treatment of moderate acne on the face and trunk.