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Common causes of thrombocytopenia in pregnancy

31 Aug 2017
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Pregnancy-associated thrombocytopenia (PAT), hypertensive disorder in pregnancy (PIH) and idiopathic thrombocytopenia (ITP) are common causes of thrombocytopenia in pregnant women, a new observational study has shown.

The study included 195 pregnant women (mean age 28.3±4.2 years) with thrombocytopenia complications, of which 60 percent (n=117) were caused by PAT, 28.2 percent (n=55) by ITP and 11.8 percent (n=23) by PIH. Exclusion criteria included multiple gestation and irregular examinations during pregnancy.

There were significant among-group differences in terms of maternal age (p=0.012), gestational age (p=0.000), premature delivery (p=0.000), neonatal birth weight (p=0.005) and times of pregnancy (p=0.001).

Specifically, gestational age at delivery was significantly lower in PIH and ITP patients than in PAT patients (p<0.05). Premature and low birth weight infants were significantly more common in PIH patients than in PAT or ITP patients (p<0.05).

Notably, thrombocytopenia occurred significantly earlier in ITP patients than in women with either PAT or PIH (p=0.000).

Therapy was recommended for 40.5 percent (n=79) of the participating women. Corticosteroids were given to 31 women, intravenous immunoglobulin (IVIg) to 30, and a combination of the two to 18.

Therapies were given to 23.1 percent (n=27) and 39.1 percent (n=9) of PAT and PIH patients, respectively, to increase platelet counts. Seven days after delivery, there were no significant differences in platelet counts between the treatment and nontreatment groups (p=0.309 and p=0.816, respectively).

On the other hand, 78.2 percent (n=43) of the ITP patients were administered treatments during pregnancy. Seven days after delivery, there was a significant difference in platelet counts between the treatment and nontreatment groups (p=0.049). Fifteen patients required additional therapy during the first few days after delivery.

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Most Read Articles
19 Dec 2016
The prevalence of ECG for left ventricular hypertrophy (LVH) may vary depending on the criteria used across body mass index (BMI) categories in a low cardiovascular risk cohort, suggests a new study.
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
Pearl Toh, 3 days ago
A higher dose of pitavastatin can benefit Japanese patients with stable coronary artery disease (CAD) compared with a low-dose pitavastatin, even though cardiovascular (CV) event incidence is known to be lower in Asian than Western patients, according to the REAL-CAD study presented at the AHA Scientific Sessions 2017.
01 Apr 2014
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