Most Read Articles
01 Sep 2018
High body mass index (BMI) appears to increase the risk of and worsen the outcomes for seasonal influenza, a recent study has found.
31 Aug 2018
New drug applications approved by US FDA as of 16 - 31 August 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Commensal bacteria facilitates tissue-specific responses mutually beneficial for both host and microbe

31 Mar 2016
Lymphoid-resistant commensal bacteria (LRCs) colonize the interstitial lymphoid tissues of healthy mammals.

LRCs were found to colonize murine dendritic cells and modulated cytokine production.

When tested in germ-free and antibiotic-treated mice, LRCs colonized the interstitial lymphoid tissues and induced IL-10 cytokines. Dendritic-cell-derived IL-10 and group 3 innate lymphoid cell (ILC3)-derived IL-22 were also induced.

Pro-inflammatory Th17 cell responses were limited by IL-10 while LRC colonization in the steady state was enhanced by IL-22 production.

LRCs provided host tissue protection against intestinal damage in an IL-10R-dependent manner.
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Most Read Articles
01 Sep 2018
High body mass index (BMI) appears to increase the risk of and worsen the outcomes for seasonal influenza, a recent study has found.
31 Aug 2018
New drug applications approved by US FDA as of 16 - 31 August 2018 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.