Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Combo therapy extends survival in paediatric ICU patients with S. maltophilia infection

11 Oct 2018

Critically ill children harbouring Stenotrophomonas maltophilia in the intensive care unit (ICU) may benefit from the combination treatment of trimethoprim and sulfamethoxazole, ciprofloxacin, and minocycline, suggests a recent study.

“Meticulous evaluation of central vascular access and prior treatment with carbapenems are indicated, especially for mechanically ventilated and septic children,” the investigators said.

The study identified and reviewed 31 patients and 91 isolates from blood, respiratory secretions and soft tissues. During the study period, an increase in the overall incidence of S. maltophilia infections was observed (p=0.003). There was a 61-percent all-cause crude mortality, while the attributed mortality was approximately 16 percent.

The following risk factors were associated with mortality: longer hospitalization before infection (p=0.002), septic shock (p=0.003), mechanical ventilation (p=0.004), an indwelling central vein catheter (p=0.03) and prior use of steroids (p=0.04) and carbapenems (p=0.004).

Multivariate analysis revealed the association of mortality with mechanical ventilation (p=0.02) and preinfection hospitalization days (p=0.01). Combination treatment of trimethoprim and sulfamethoxazole, ciprofloxacin and/or minocycline significantly extended survival time (p<0.001). The treatment method did not significantly affect the interval between S. maltophilia isolation to resolution of infection (p=0.2).

In this study, a retrospective chart review was conducted involving paediatric patients with isolates of S. maltophilia hospitalized over a 5-year period in two paediatric ICUs.

S. maltophilia is a life-threatening nosocomial pathogen with profound multidrug-resistant attributes. It is associated with high mortality, particularly in immunocompromised patients. Data on therapy for S. maltophilia infections are scarce, especially in children hospitalized in intensive care settings (paediatric ICU),” the investigators said.

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Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.