Most Read Articles
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.

Combined first-trimester screening most effective for testing foetal down syndrome

24 Jun 2020
It was speculated that the family’s wish for a second child in a short period of time might be the reason why they allegedly refused permission for a C-section delivery.

Combined first-trimester screening (CFTS) appears to be the best traditional method for the diagnosis of foetal down syndrome, a recent study has found.

Of the 21,713 pregnant mothers who underwent CFTS, 370 (1.7 percent), 732 (3.37 percent), and 20,611 (94.92 percent) were classified as high, intermediate, and low risk, respectively. In comparison, the number of participants who underwent double, triple, and quadruple screening was 68,512, 13,692, and 8,087, respectively.

CFTS yielded the smallest proportion of high- and intermediate-risk mothers, as compared to the other traditional testing methods (p<0.01).

Despite this, the detection rate for high-risk patients was highest in CFTS (78.79 percent), as opposed to the quadruple, triple, and double screening (72.73 percent, 69.23 percent, and 70.0 percent, respectively). The discrepancy, however, was only nominal (p=0.829).

At a high-risk cut-off of 1:270, CFTS demonstrated a true negative rate of 98.41 percent, higher than that in the quadruple (96.31 percent), triple (97.09 percent), and double (94.76 percent) screenings. Conversely, the false positive rate in CFTS was lower than in the other methods (1.59 percent vs 3.69 percent, 2.91 percent, and 5.24 percent, respectively).

The positive predictive rate of CFTS was likewise superior.

“Our study demonstrated if only one traditional screening test is allowed to screen pregnant women, CFTS is recommended as the first choice. CFTS can reduce the number of noninvasive prenatal screenings, thus reducing the cost of health economics,” the researchers said.

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Most Read Articles
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.