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Combination therapy plus IPP insertion safe, effective in patients with Peyronie’s disease

09 Sep 2018

A combined approach of intraoperative and postoperative therapies as well as an inflatable penile prosthesis (IPP) in the treatment of Peyronie’s disease has been shown to be safe and effective with excellent functional outcomes, according to a study. Additionally, penile curvature corrections are statistically significant, while complications are negligible.

Endocavernous disruption of Peyronie’s disease plaques via the scratch technique was conducted in 145 patients, followed by IPP insertion. Patients were then postoperatively assigned to vacuum device therapy for 3 minutes twice daily to continue penile curvature correction. Follow-up lasted for 1 year after surgery. The authors then assessed anatomical and functional results.

Mean postoperative residual curvature was 21.5±4.5, 17.3±4.8 and 14.1±3.1 degrees among patients with plaques in the proximal third, middle third and subcoronal areas of the penis, respectively. Mean penile curvature deviation after 24 weeks of vacuum therapy decreased to 8.7±2.5, 9.1±2.9 and 7.7±0.9 degrees, respectively.

The corresponding mean IIEF-5 (International Index of Erectile Function) scores preoperatively, at 6 months (p<0.001) and at 1 year (p<0.001) were 9.8±2.3, 18.9±3.1 and 24.1±3.6. At the end of follow-up, mean EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction) score was 64.6±11.8. Moreover, there were minimal operative and postoperative complications.

A study by Chung and colleagues has shown that insertion of IPP with synchronous penile plication for the correction of erectile dysfunction and Peyronie’s disease is effective and leads to high patient satisfaction. [J Sex Med 2014;11:1593-1598]

“Peyronie’s disease is a devastating condition resulting in penile malformation, erectile dysfunction, pain and emotional distress,” the authors noted.

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Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
5 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).