Most Read Articles
Tristan Manalac, 4 days ago
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Pearl Toh, 3 days ago
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Combination therapy plus IPP insertion safe, effective in patients with Peyronie’s disease

09 Sep 2018

A combined approach of intraoperative and postoperative therapies as well as an inflatable penile prosthesis (IPP) in the treatment of Peyronie’s disease has been shown to be safe and effective with excellent functional outcomes, according to a study. Additionally, penile curvature corrections are statistically significant, while complications are negligible.

Endocavernous disruption of Peyronie’s disease plaques via the scratch technique was conducted in 145 patients, followed by IPP insertion. Patients were then postoperatively assigned to vacuum device therapy for 3 minutes twice daily to continue penile curvature correction. Follow-up lasted for 1 year after surgery. The authors then assessed anatomical and functional results.

Mean postoperative residual curvature was 21.5±4.5, 17.3±4.8 and 14.1±3.1 degrees among patients with plaques in the proximal third, middle third and subcoronal areas of the penis, respectively. Mean penile curvature deviation after 24 weeks of vacuum therapy decreased to 8.7±2.5, 9.1±2.9 and 7.7±0.9 degrees, respectively.

The corresponding mean IIEF-5 (International Index of Erectile Function) scores preoperatively, at 6 months (p<0.001) and at 1 year (p<0.001) were 9.8±2.3, 18.9±3.1 and 24.1±3.6. At the end of follow-up, mean EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction) score was 64.6±11.8. Moreover, there were minimal operative and postoperative complications.

A study by Chung and colleagues has shown that insertion of IPP with synchronous penile plication for the correction of erectile dysfunction and Peyronie’s disease is effective and leads to high patient satisfaction. [J Sex Med 2014;11:1593-1598]

“Peyronie’s disease is a devastating condition resulting in penile malformation, erectile dysfunction, pain and emotional distress,” the authors noted.

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Most Read Articles
Tristan Manalac, 4 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 3 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
2 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.