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Combination therapy plus IPP insertion safe, effective in patients with Peyronie’s disease

09 Sep 2018

A combined approach of intraoperative and postoperative therapies as well as an inflatable penile prosthesis (IPP) in the treatment of Peyronie’s disease has been shown to be safe and effective with excellent functional outcomes, according to a study. Additionally, penile curvature corrections are statistically significant, while complications are negligible.

Endocavernous disruption of Peyronie’s disease plaques via the scratch technique was conducted in 145 patients, followed by IPP insertion. Patients were then postoperatively assigned to vacuum device therapy for 3 minutes twice daily to continue penile curvature correction. Follow-up lasted for 1 year after surgery. The authors then assessed anatomical and functional results.

Mean postoperative residual curvature was 21.5±4.5, 17.3±4.8 and 14.1±3.1 degrees among patients with plaques in the proximal third, middle third and subcoronal areas of the penis, respectively. Mean penile curvature deviation after 24 weeks of vacuum therapy decreased to 8.7±2.5, 9.1±2.9 and 7.7±0.9 degrees, respectively.

The corresponding mean IIEF-5 (International Index of Erectile Function) scores preoperatively, at 6 months (p<0.001) and at 1 year (p<0.001) were 9.8±2.3, 18.9±3.1 and 24.1±3.6. At the end of follow-up, mean EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction) score was 64.6±11.8. Moreover, there were minimal operative and postoperative complications.

A study by Chung and colleagues has shown that insertion of IPP with synchronous penile plication for the correction of erectile dysfunction and Peyronie’s disease is effective and leads to high patient satisfaction. [J Sex Med 2014;11:1593-1598]

“Peyronie’s disease is a devastating condition resulting in penile malformation, erectile dysfunction, pain and emotional distress,” the authors noted.

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Most Read Articles
6 days ago
Electroretinogram-assessed localized retinal dysfunction in type 1 diabetes mellitus patients appears to occur even in the absence of clinical signs of diabetic retinopathy (DR), and this incidence is associated with ageing, according to a study.
Roshini Claire Anthony, 19 hours ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 3 days ago
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
6 days ago
Greater home blood pressure (BP) variability, particularly in home systolic (S)BP, correlates with higher carotid, aortic and peripheral but not coronary atherosclerosis burdens independent of the mean home BP, suggests a recent study.