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Combination therapy plus IPP insertion safe, effective in patients with Peyronie’s disease

09 Sep 2018

A combined approach of intraoperative and postoperative therapies as well as an inflatable penile prosthesis (IPP) in the treatment of Peyronie’s disease has been shown to be safe and effective with excellent functional outcomes, according to a study. Additionally, penile curvature corrections are statistically significant, while complications are negligible.

Endocavernous disruption of Peyronie’s disease plaques via the scratch technique was conducted in 145 patients, followed by IPP insertion. Patients were then postoperatively assigned to vacuum device therapy for 3 minutes twice daily to continue penile curvature correction. Follow-up lasted for 1 year after surgery. The authors then assessed anatomical and functional results.

Mean postoperative residual curvature was 21.5±4.5, 17.3±4.8 and 14.1±3.1 degrees among patients with plaques in the proximal third, middle third and subcoronal areas of the penis, respectively. Mean penile curvature deviation after 24 weeks of vacuum therapy decreased to 8.7±2.5, 9.1±2.9 and 7.7±0.9 degrees, respectively.

The corresponding mean IIEF-5 (International Index of Erectile Function) scores preoperatively, at 6 months (p<0.001) and at 1 year (p<0.001) were 9.8±2.3, 18.9±3.1 and 24.1±3.6. At the end of follow-up, mean EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction) score was 64.6±11.8. Moreover, there were minimal operative and postoperative complications.

A study by Chung and colleagues has shown that insertion of IPP with synchronous penile plication for the correction of erectile dysfunction and Peyronie’s disease is effective and leads to high patient satisfaction. [J Sex Med 2014;11:1593-1598]

“Peyronie’s disease is a devastating condition resulting in penile malformation, erectile dysfunction, pain and emotional distress,” the authors noted.

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Most Read Articles
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.