Colonization with small conidia Aspergillus species was found to increase the risk of bronchiolitis obliterans syndrome and death
01 Apr 2013
Bronchiolitis obliterans syndrome (BOS) is the most common cause of chronic lung allograft dysfunction. After lung transplantation, development of BOS may affect long-term survival. Previous studies suggested that Aspergillus colonization may lead to an increase in the risk of BOS. This study determined the impact of colonization of small and large conidia Aspergillus species post lung transplantation in two large independent cohorts. 298 participants from the University of California and 482 from the Duke University Medical Center were observed. Colonization with small conidia Aspergillus species was found to increase the risk of BOS and death.