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Colchicine shows therapeutic potential in COVID-19

24 Aug 2020

Colchicine, which is used to treat gout and other inflammatory disorders, appears to improve survival rate in patients with COVID-19 as compared with standard of care (SoC), as shown in a study.

The drug was considered for the treatment of COVID-19 based on its well-recognised anti-inflammatory effects and potential antiviral properties, according to researchers. In the study, they evaluated outcomes in 140 hospitalized COVID-19 patients who were treated with SoC (hydroxychloroquine and/or intravenous dexamethasone; and/or lopinavir/ritonavir) and in 122 patients treated with colchicine (1 mg/day) and SoC (antiviral drugs were stopped before colchicine, due to potential interaction).

At baseline, the SoC group showed lower serum concentrations of C-reactive protein and ferritin, as well as neutrophil count, but higher PaO2/FiO2 ratio.

Over 21 days of follow-up, survival was more favourable in the colchicine than the SoC group (84.2 percent vs 63.6 percent; p=0.001). On Cox proportional hazards regression survival analysis, colchicine use was strongly associated with a lower risk of death (hazard ratio, 0.151, 95 percent confidence interval, 0.062–0.368; p<0.0001).

Risk factors for poor survival included older age, worse PaO2/FiO2, and higher serum levels of ferritin at entry.

Colchicine had a good safety profile, with no treatment discontinuation due to severe adverse events. Dosing was reduced from 1 to 0.5 mg/day in nine patients (7.4 percent) due to diarrhoea.

The current study provides proof-of-concept data supporting the possible use of colchicine in the treatment of the early phase of COVID-19, with the aim of preventing the patient’s autoinflammatory response, the researchers said.

Properly designed trials are needed to determine the efficacy and safety of colchicine and the best protocol in terms of dosage and timing of administration in patients with COVID-19, they added.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
4 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
Pearl Toh, 3 days ago
Quadrivalent human papillomavirus (HPV) vaccination can substantially reduce the risk of invasive cervical cancer, by up to almost 90 percent in women who were vaccinated early, a large Swedish registry-based study has shown.