Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Cognitive impairment linked to early death in haemodialysis patients

19 Oct 2019

Haemodialysis patients with cognitive impairment are at risk of premature mortality, which does not appear be associated with education, according to data from the COGNITIVE-HD Study.

The study included 676 adult haemodialysis patients (median age, 70.9 years; 38.8 percent female) treated in 20 Italian dialysis clinics. All patients underwent a neuropsychological assessment to determine cognitive function across the following domains: memory, attention, executive function, language and perceptual-motor function.

Of the 664 patients with complete data, 527 (79.4 percent) had cognitive impairment. A total of 206 deaths occurred during a median follow-up of 3.3 years (1,874 person-years).

Nested multivariable Cox regression models showed that patients with any cognitive impairment had a 77-percent higher risk of mortality relative to those without impairment (hazard ratios [HR], 1.77, 95 percent CI, 1.07–2.93). The corresponding HRs associated with one, two and three-to-five domains impaired were 1.48 (0.82–2.68), 1.88 (1.01–3.53) and 2.01 (1.14–3.55).

On the other hand, every standard deviation increase in global cognitive function score was associated with a 32-percent reduction in mortality risk (HR, 0.68, 0.51–0.92).

Compared with patients with primary or lower education, those with lower secondary or upper secondary/higher had HRs for mortality of 0.79 (0.53–1.20) and 1.13 (0.80–1.59), respectively. The cognition-by-education interaction was not significant (p=0.7).

The study was limited by potential selection bias from nonparticipation, lack of data on cognitive decline and the inability to control for other socioeconomic factors.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.