Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Coffee intake does not increase ovarian cancer risk

21 Oct 2019

Drinking coffee, regardless of the variety, appears to have no significant role in the risk of ovarian cancer, according to the findings of a systematic review and meta-analysis.

“Prospective studies on caffeine and different types of coffee intake in relation to the risk of ovarian cancer have shown conflicting results,” the investigators said.

To address this issue, a dose-response meta-analysis of cohort studies was conducted. The following databases were searched to identify relevant studies reported until October 2018: PubMed/Medline, ISI Web of Science, Scopus and Embase.

Included were prospective cohort studies that considered caffeine or different coffee types as the exposure variable and ovarian cancer as the main outcome variable or as one of the outcome variables. Two reviewers independently screened 9,344 publications and extracted the data. Disagreements were resolved by consulting with the principal investigator.

Fourteen cohort studies met the inclusion criteria. A total of 13 effect sizes were combined, but there was no substantial association found between coffee intake and the risk of ovarian cancer (risk ratio [RR], 1.08, 95 percent CI, 0.89–1.33). However, drinking one additional cup of coffee daily was found to be marginally associated with an increased risk of ovarian cancer (RR, 1.02, 0.99–1.05; p=0.21; I2, 0.0 percent; p-heterogeneity=0.68).

In addition, there was no statistically significant association seen between caffeine consumption or caffeinated or decaffeinated coffee intake and the risk of ovarian cancer.

A 2008 study which also found no significant association between coffee intake and ovarian cancer incidence suggested that a component of coffee other than caffeine, or in combination with caffeine, may be associated with a higher risk of ovarian cancer in postmenopausal women who drink 5 cups of coffee a day. [Cancer Causes Control 2008;19:1365-1372]

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.