Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Coexistence of spondyloarthritis, Takayasu arteritis may not be coincidental

21 Jul 2017

The association of spondyloarthritis (SpA) with Takayasu arteritis (TA) in a single patient is unusual but probably not coincidental, a recent study suggests.

In patients with SpA, the first indicators of TA are peripheral pulse palpation and vascular auscultation, which should be systematic. In addition, elevated acute-phase reactants during SpA follow-up must lead to search for TA.

“Finally, there are therapeutic implications because anti-tumour necrosis factor (TNF) is efficient in SpA and might be efficient in TA,” researchers said.

In this French multicentre retrospective survey, the investigators established a standardized questionnaire to describe clinical features of patients having SpA associated with TA and to identify some characteristics of the types of patients with SpA associated with TA. Treatments used in this context were also assessed.

The participants included 14 patients (median age at SpA diagnosis 43.5 years; range, 19 to 63 years; 10 women). Subtypes of SpA included ankylosing spondylitis (n=11), psoriatic arthritis (n=2), and synovitis, acne, pustulosis, hyperostosis and osteitis syndrome (n=1).

There were three positive cases of HLA-B27, nine negative and two unknown. SpA was detected before TA in 13 cases. Imaging findings compatible with the diagnosis of TA were discovered using computed tomography (11/14) and/or Doppler ultrasound (10/14).

Laboratory tests exhibited increased acute-phase reactants in all cases (C-reactive protein ≥25 mg/l in 71 percent of the cases). There were 13 patients who received corticosteroids and seven administered with anti-TNF.

SpA and TA are chronic inflammatory diseases that may coexist in a single patients, although such coexistence is rare, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.