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Stephen Padilla, 6 days ago
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Coeliac disease ups risk of IBD and vice versa

19 Jul 2019

Patients with coeliac disease are at increased risk of inflammatory bowel disease (IBD), while those with IBD have, to a lesser extent, a higher risk of coeliac disease, according to a study.

A total of 41,482 adult IBD patients (20,357 with Crohn’s disease; 19,791 with ulcerative colitis; 459 with coeliac disease) were included.

In IBD patients, coeliac disease had a prevalence of 1,110/100,000 (95 percent CI, 1,010–1,210) as compared with 620/100,000 (610–630) in the respective populations (odds ratio [OR], 2.23, 1.99–2.50). On the other hand, the prevalence of IBD in patients with coeliac disease was 2,130/100,000 (1,590–2,670) as compared with 260/100,000 (250–270) in the respective populations (OR, 11.10, 8.55–14.40).

Such effect was not unlike that for cases of ulcerative colitis and Crohn’s disease.

No evidence for publication bias was observed for coeliac disease in IBD, but the funnel plot indicated that the association for IBD in coeliac disease might be influenced by publication bias.

To assess the risk of coeliac disease in IBD patients and the risk of IBD in coeliac disease patients, the investigators identified 1,525 publications initially using the search terms “inflammatory bowel disease” and “celiac disease.” Of these, 27 studies were included in the analysis.

The investigators then compared proportions and 95 percent CIs for the prevalence of IBD in coeliac disease and vice versa with published prevalence rates for the respective geographic regions.

Previous studies report a possible association between IBD and coeliac disease,” they noted. “[H]owever, this link is controversial.”

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
2 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.