Most Read Articles
Pearl Toh, 4 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.

Coeliac disease linked to depression among young T1D patients

5 days ago

Among young people type 1 diabetes (T1D), those with coeliac disease (CD) are also more likely to have depression, according to a study, suggesting that the double burden of T1D and CD may increase susceptibility to depression.

The study included 79,067 participants aged 6–20 years who had at least 6 months of diabetes duration. Of these, 73,699 had T1D only (reference group), 3,379 (4.3 percent) had CD, 1,877 (2.4 percent) had comorbid depression, and 112 (0.1 percent) had both CD and depression.

Compared with the reference group, patients with CD and those with depression (with or without additional CD) were older (p<0.001 for all). There were more women than men in the three CD/depression groups (p<0.001 for all), while pump usage was more common in T1D + CD and in T1D + depression groups (p<0.001 both) than in the reference group.

Multivariable logistic regression models showed a significant association between CD and depression (adjusted odds ratio, 1.25, 95 percent confidence interval [CI], 1.03–1.53).

There were other notable differences observed among the patient groups. HbA1c was higher in the T1D + depression (9.0 percent) and T1D + CD + depression (8.9 percent) groups than in the reference group (8.2 percent; p<0.001 for both comparisons).

Meanwhile, comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders were more common in the T1D + CD + depression versus the reference group (p<0.001).

The findings indicate that having T1D and additional CD is a heavier burden than having only one chronic disease. Regular screening for CD and depression may help improve outcomes for these patients.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 4 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Elvira Manzano, 3 days ago
An investigational transdermal amphetamine patch worn for 9 hours on the hip appeared effective in paediatric patients with attention deficit-hyperactivity disorder (ADHD) in a phase II, two-part trial.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.