Most Read Articles
Stephen Padilla, 21 hours ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 3 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
6 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.

Coeliac disease a risk factor for inflammatory bowel disease

08 Jun 2018

Patients with coeliac disease have more than an 11-fold increased risk of developing inflammatory bowel disease (IBD), whereas those with IBD have only a twofold higher risk of developing coeliac disease, a study has found.

Researchers performed a systematic review and meta-analysis of studies investigating the association between coeliac disease and IBD. Only studies that reported original data, used clinically established methods to diagnose coeliac disease or IBD, and reported on the prevalence rate of IBD in coeliac disease or vice versa were included.

The analysis included 27 studies corresponding to 41,482 adult IBD patients (20,357 with Crohn’s disease; 19,791 with ulcerative colitis), 1,295 non-IBD controls, 2,769 patients with coeliac disease and 4,854 controls without coeliac disease.

Based on pooled data, the prevalence rate of coeliac disease in IBD patients was 1,110 (95 percent CI, 1,010–1,210) per 100,000 as compared with 620 (610–630) per 100,000 in non-IBD controls (odds ratio [OR], 2.23; 1.99–2.50). This effect did not differ between ulcerative colitis and Crohn’s disease.

On the other hand, the prevalence of IBD in patients with coeliac disease was 2,130 per 100,000 as compared with 260 (250–270) per 100,000 in the corresponding control population (OR, 11.10; 8.55–14.40).

Funnel plot indicated that the risk of IBD in coeliac disease was possibly influenced by publication bias, while there was no evidence for publication bias for the risk of coeliac disease in IBD.

While the exact mechanism of the association between coeliac disease and risk of IBD has yet to be explored, researchers postulated that it may be related to the mucosal inflammation associated with coeliac disease. This inflammation in turn initiates a sequel of events that ultimately result in IBD.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 21 hours ago
Treatment with oral thrombopoietin receptor agonist eltrombopag leads to similar platelet counts in patients with chronic immune thrombocytopaenia (cITP) and persistent (per)ITP, according to the results of phase III (EXTEND) and IV studies presented at the 23rd Congress of the European Hematology Association (EHA 2018) held in Stockholm, Sweden.
Pearl Toh, 3 days ago
Lonely people were twice as likely to die from any cause than people who did not feel lonely, according to a study based on a national survey presented at the recent EuroHeartCare 2018 in Dublin, Ireland. Also, loneliness is associated with poorer patient-reported outcomes in terms of mental and physical health in patients with heart disease.
6 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
6 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.