Most Read Articles
26 Jun 2020

Achieving standard of care targets, such as reduced levels of low-density lipoprotein cholesterol and glycated haemoglobin, improves outcomes in coronary heart disease patients, a new study has found.

Dr. Joseph Delano Fule Robles, 24 Jul 2018

Functional foods benefit the body beyond its nutritional effects, with studies showing that they can improve general state of health and reduce the risk of diseases.

29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
23 May 2020
Small dense low-density lipoprotein cholesterol (sd-LDL-C) is a strong predictor of stroke severity and intracranial artery calcification (IAC) in patients with acute ischaemic stroke (AIS), a study has shown.

Cocoa confers benefits for walking in older adults with peripheral artery disease

11 May 2020

Cocoa improves walking performance in elderly patients with peripheral artery disease (PAD), according to the results of a phase II trial.

The trial randomized 44 PAD patients (mean age, 72.3 years; 66 percent male; mean ankle brachial index, 0.66) to consume either a flavanol-rich cocoa beverage (n=23) or an identically appearing placebo beverage (n=21) thrice daily for 6 months. The cocoa beverage had 15 g of cocoa and 75 mg of epicatechin daily, while the placebo beverage contained neither.

Adherence rates, measured based on packet counts, were 68 percent in the cocoa group and 80 percent in the placebo group. Six-month change in epicatechin metabolites and theobromine was significantly greater in patients who drank cocoa, consistent with good adherence. A total of 40 patients (91 percent) completed follow-up.

At the 6-month follow-up, the 6-minute walking distance (6MWD) measured 2.5 hours after drinking the final study beverage improved by 42.6 metres with cocoa vs placebo (p=0.005). Cocoa consumption also improved the 6MWD measured 24 hours after final study beverage intake by 18.0 metres, although the difference was not significant relative to placebo (p=0.12).

In calf muscle biopsies, patients in the cocoa vs placebo group showed marked improvements in mitochondrial COX (cytochrome c oxidase) activity (p=0.013) and calf muscle perfusion (p=0.098), an increase in capillary density (p=0.014), and a reduction in central nuclei (p=0.033).

Further study is needed to establish the benefits of cocoa to patients with PAD.

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Most Read Articles
26 Jun 2020

Achieving standard of care targets, such as reduced levels of low-density lipoprotein cholesterol and glycated haemoglobin, improves outcomes in coronary heart disease patients, a new study has found.

Dr. Joseph Delano Fule Robles, 24 Jul 2018

Functional foods benefit the body beyond its nutritional effects, with studies showing that they can improve general state of health and reduce the risk of diseases.

29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
23 May 2020
Small dense low-density lipoprotein cholesterol (sd-LDL-C) is a strong predictor of stroke severity and intracranial artery calcification (IAC) in patients with acute ischaemic stroke (AIS), a study has shown.