Most Read Articles
29 Jul 2020
Adjunctive perampanel appears to be safe and effective for long-term treatment of patients with tonic‐clonic seizures, according to a posthoc analysis.
Pearl Toh, 6 days ago
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Elvira Manzano, 20 Jun 2018
A higher proportion of patients with systemic lupus erythematosus (SLE) experienced improvements in joint and skin symptoms with baricitinib 4 mg once daily vs placebo in a phase II randomized, double-blind, global study.

Coadministration of sorafenib, gastric acid suppressants spells trouble in advanced HCC

22 Jun 2020

Taking sorafenib and gastric acid suppression therapy together may be bad for patients with advanced hepatocellular carcinoma (HCC), as the combination translates to significantly lower survival, as shown in a study.

Researchers looked at 197 patients treated with sorafenib for advanced liver cancer at a single tertiary referral unit in the UK, among whom 182 were included in the analysis. There were 77 patients who had been on concurrent gastric acid suppression therapy.

A multivariate Cox proportional hazard model revealed that patients who were taking acid suppression therapy concomitantly with sorafenib had poorer survival outcomes compared with those who were not on gastric acid suppressants.

The resulting adjusted hazard ratios were 5.4 (95 percent confidence interval [CI], 3.6–7.9) for progression-free survival (PFS) and 1.85 (95 percent CI, 1.3–2.6) for overall survival.

It has been previously shown that coadministration of gastric acid suppressants reduces the efficacy of the tyrosine kinase inhibitors erlotinib and sunitinib in patients with nonsmall cell lung cancer and renal cell carcinoma, respectively. The researchers emphasized that the current data is the first report of a negative interaction between acid suppression therapy and sorafenib in advanced HCC.

The findings should be validated in prospective studies, they added.

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Most Read Articles
29 Jul 2020
Adjunctive perampanel appears to be safe and effective for long-term treatment of patients with tonic‐clonic seizures, according to a posthoc analysis.
Pearl Toh, 6 days ago
The direct oral anticoagulant apixaban may help prevent deaths when given at prophylactic or therapeutic doses in hospitalized COVID-19 patients with elevated D-dimer levels, according to an analysis presented during the ISTH 2020 Congress.
Elvira Manzano, 20 Jun 2018
A higher proportion of patients with systemic lupus erythematosus (SLE) experienced improvements in joint and skin symptoms with baricitinib 4 mg once daily vs placebo in a phase II randomized, double-blind, global study.