Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
2 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
6 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
5 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.

Clostridium difficile infection reduces survival in patients undergoing alloHCT

28 Sep 2019

Clostridium difficile (CD) infection remains high in patients with acute myeloid leukaemia (AML) or myelodysplasia syndrome (MDS) undergoing allogeneic haematopoietic stem cell transplantation (alloHCT), a recent study has shown.  Moreover, patients with CD infection appear to have a significantly lower overall survival.

“Recipients of alloHCT are at high risk for CD infection, but large studies in this population are rare and conflicting results have been reported,” according to the authors.

A total of 727 patients with AML or MDS undergoing alloCHT from 2004 to 2015 were included in the analysis. Of these, 96 (13 percent) had CD infection and 103 (14 percent) were identified as asymptomatic carriers by screening at admission and once a week during aplasia.

Median overall survival was shorter among patients with CD infection compared with those without the infection (with vs without CD infection: 8 months, 95 percent CI, 6–36 months vs 25 months, 17–35 months; hazard ratio [HR], 1.4; p=0.04).

On the other hand, patients with CD infection were less likely to develop acute graft-versus-host disease (aGvHD; HR, 0.6; p=0.004) compared with those without the infection. However, no between-group differences were seen in gastrointestinal aGvHD (HR, 0.9; p=0.5). Gastrointestinal aGvHD occurred more frequently in symptomatic patients (HR, 2.5; p=0.02) than in asymptomatic CD-positive patients.

“CD infection is the main cause of nosocomial enterocolitis in western countries and in patients undergoing alloHCT,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
2 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
6 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
5 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.