Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Clostridium difficile infection reduces survival in patients undergoing alloHCT

28 Sep 2019

Clostridium difficile (CD) infection remains high in patients with acute myeloid leukaemia (AML) or myelodysplasia syndrome (MDS) undergoing allogeneic haematopoietic stem cell transplantation (alloHCT), a recent study has shown.  Moreover, patients with CD infection appear to have a significantly lower overall survival.

“Recipients of alloHCT are at high risk for CD infection, but large studies in this population are rare and conflicting results have been reported,” according to the authors.

A total of 727 patients with AML or MDS undergoing alloCHT from 2004 to 2015 were included in the analysis. Of these, 96 (13 percent) had CD infection and 103 (14 percent) were identified as asymptomatic carriers by screening at admission and once a week during aplasia.

Median overall survival was shorter among patients with CD infection compared with those without the infection (with vs without CD infection: 8 months, 95 percent CI, 6–36 months vs 25 months, 17–35 months; hazard ratio [HR], 1.4; p=0.04).

On the other hand, patients with CD infection were less likely to develop acute graft-versus-host disease (aGvHD; HR, 0.6; p=0.004) compared with those without the infection. However, no between-group differences were seen in gastrointestinal aGvHD (HR, 0.9; p=0.5). Gastrointestinal aGvHD occurred more frequently in symptomatic patients (HR, 2.5; p=0.02) than in asymptomatic CD-positive patients.

“CD infection is the main cause of nosocomial enterocolitis in western countries and in patients undergoing alloHCT,” the authors said.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.