Most Read Articles
Elaine Soliven, 27 Sep 2017
A second dose of kisspeptin-54 improves oocyte yield in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) treatment, according to a recent study.
23 Oct 2017
Pearl Toh spoke with Dr Teh Ming Ming, senior consultant at the Department of Endocrinology, Singapore General Hospital (SGH), on the major challenges of diagnosing and managing diabetes in primary care, in conjunction with the World Diabetes Day on 14 November. Awareness of the symptoms of diabetes is important, and patients should be empowered to manage their conditions.
Rachel Soon, Yesterday

Pharmacists can and should utilize their positions within communities to provide access to an extended range of healthcare services, says an expert.

01 Aug 2017
New drug applications approved by US FDA as of 1 - 15 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Clomiphene citrate improves cycle characteristics, impairs IVF outcomes

06 Sep 2017
 Clomiphene citrate (CC) enhances cycle characteristics but may lead to poorer in vitro fertilization (IVF) outcomes in obese females with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation for IVF, a recent study has found.

Investigators divided 174 obese women with PCOS undergoing IVF into two groups according to treatments received: those who were given CC with human menopausal gonadotropin (HMG) and medroxyprogesterone acetate (MPA; n=90), and those who received HMG and MPA only (control; n=84).

HMG dose was significantly lower in the HMG+MPA+CC group (1,650 IU) compared with the control group (2,025 IU; p=0.0002038). In contrast, HMG stimulation duration between the two groups were comparable (11 vs 12 days; p=0.077).

The number of oocytes retrieved was significantly higher in the control group than in the study group (13 vs 5; p=0.0000016), while the time from trigger to retrieval of oocytes was comparable between groups.

The control group also had significantly higher numbers of mature oocytes (11 vs 4; p=0.00000386), fertilized oocytes (8 vs 4; p=0.000081) and cleaved embryos (8.5 vs 4 p=0.0000633) compared with the HMG+MPA+CC group.

The number of high quality embryos were also significantly greater in the control group than in the study group (3.5 vs 2; p=0.003).

Recruited participants underwent transvaginal ultrasound to measure antral follicle count and follicle size. Serum concentrations of relevant hormones were also recorded. The primary study outcome was the number of oocytes retrieved, while secondary outcomes included maturation rate, number of high quality embryos and fertilization rate.

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Most Read Articles
Elaine Soliven, 27 Sep 2017
A second dose of kisspeptin-54 improves oocyte yield in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) treatment, according to a recent study.
23 Oct 2017
Pearl Toh spoke with Dr Teh Ming Ming, senior consultant at the Department of Endocrinology, Singapore General Hospital (SGH), on the major challenges of diagnosing and managing diabetes in primary care, in conjunction with the World Diabetes Day on 14 November. Awareness of the symptoms of diabetes is important, and patients should be empowered to manage their conditions.
Rachel Soon, Yesterday

Pharmacists can and should utilize their positions within communities to provide access to an extended range of healthcare services, says an expert.

01 Aug 2017
New drug applications approved by US FDA as of 1 - 15 June 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.