Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.

Clomiphene citrate improves cycle characteristics, impairs IVF outcomes

06 Sep 2017
 Clomiphene citrate (CC) enhances cycle characteristics but may lead to poorer in vitro fertilization (IVF) outcomes in obese females with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation for IVF, a recent study has found.

Investigators divided 174 obese women with PCOS undergoing IVF into two groups according to treatments received: those who were given CC with human menopausal gonadotropin (HMG) and medroxyprogesterone acetate (MPA; n=90), and those who received HMG and MPA only (control; n=84).

HMG dose was significantly lower in the HMG+MPA+CC group (1,650 IU) compared with the control group (2,025 IU; p=0.0002038). In contrast, HMG stimulation duration between the two groups were comparable (11 vs 12 days; p=0.077).

The number of oocytes retrieved was significantly higher in the control group than in the study group (13 vs 5; p=0.0000016), while the time from trigger to retrieval of oocytes was comparable between groups.

The control group also had significantly higher numbers of mature oocytes (11 vs 4; p=0.00000386), fertilized oocytes (8 vs 4; p=0.000081) and cleaved embryos (8.5 vs 4 p=0.0000633) compared with the HMG+MPA+CC group.

The number of high quality embryos were also significantly greater in the control group than in the study group (3.5 vs 2; p=0.003).

Recruited participants underwent transvaginal ultrasound to measure antral follicle count and follicle size. Serum concentrations of relevant hormones were also recorded. The primary study outcome was the number of oocytes retrieved, while secondary outcomes included maturation rate, number of high quality embryos and fertilization rate.

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Most Read Articles
Pearl Toh, 18 Feb 2016
Treatment with eluxadoline, a new oral medication, relieved two major symptoms of irritable bowel syndrome with diarrhoea (IBS-D) — abdominal pain and diarrhoea, according to a study based on two phase III randomized controlled trials. [N Engl J Med 2016;374:242-253]
Su Ping Chuah, 01 Aug 2014

The Lancet has launched a special series issue that highlights the global HIV epidemic among sex workers, a key but overlooked population for HIV prevention. The series – launched at the 20th International AIDS conference in Melbourne – consists of seven papers that aim to investigate the complex health issues faced by sex workers worldwide, and calls for the decriminalization of sex work, in the global effort to tackle the HIV/AIDS epidemic. [Available at www.thelancet.com/series/HIV-and-sex-workers. Accessed on 23 July 2014]

01 Apr 2016
Amiodarone is safe and effective for early junctional ectopic tachycardia prophylaxis in paediatric patients following open heart surgery, based on a study.
Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.