Most Read Articles
3 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Jairia Dela Cruz, 3 days ago
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Clinical guide needed to improve management of cat-scratch disease

11 Nov 2020
Relevant authorities have been running inspections on stray and pet dogs and cats.

Certain concerns have been raised regarding the serologic diagnosis of cat-scratch disease (CSD), which include the use of low titres for positivity, incomplete diagnostic evaluation, and the lack of convalescent serologic testing, reveals a study.

“We propose a clinical guide to assist in managing suspected cases of CSD,” the authors said.

A retrospective chart review of immunocompetent paediatric patients was carried out at the Hospital for Sick Children in Toronto, Canada, spanning a period of 11 years. In total, 154 cases were included with serologic titres ≥1:128. These were further divided into the following groups: group 1=1:128; group 2=1:256; and group 3 ≥1:512.

The authors evaluated cases within groups with respect to cat contact, clinical presentation, further testing, and final diagnosis.

Among patients with a titre of 1:128, one-third had an alternative diagnosis. Most patients with a titre of 1:128 or 1:256 did not undergo convalescent serologic testing. Only one case within these two groups had a fourfold rise in the convalescent titre.

Furthermore, there was a trend of decreasing number of patients with alternative diagnoses (p=0.03) and increasing number of patients presenting with regional lymphadenopathy (p=0.07) which correlated with higher titres in group 3 compared with group 1.

Bartonella henselae serology is commonly used to diagnose CSD, with titres above a threshold for positivity suggesting either a recent or remote infection. A fourfold increase in the convalescent titre in some cases could confirm a recent infection.

“Many atypical presentations attributed to CSD utilize a low threshold for positivity without supportive evidence from convalescent sera or supplemental testing, raising a concern for the overdiagnosis of CSD,” the authors said.

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Most Read Articles
3 days ago
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Jairia Dela Cruz, 3 days ago
The selective serotonin reuptake inhibitor escitalopram holds promise in the prevention of Alzheimer’s disease, reducing amyloid-β-42 levels in cerebrospinal fluid and brain tissue in older adults with normal cognitive function, according to recent evidence.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.