Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Clinical congestion persists after intensive treatment in heart failure patients

17 Oct 2019

While intensive treatment decreases the prevalence of clinical congestion, it remains sufficiently common in patients with heart failure, a recent study has found.

The study included 588 patients (mean age, 77±8 years; 60 percent male) with chronic heart failure and New York Heart Association (NYHA) functional class II. The primary study outcomes were survival and hospitalization-free heart failure survival. Congestion-related signs and symptoms analysed were NYHA III, orthopnoea, paroxysmal nocturnal dyspnoea, rales, jugular venous distension, peripheral pitting oedema and hepatomegaly.

The prevalence rates of congested-related symptoms were high at baseline but decreased over a median follow-up of 27.2 months. In the same time frame, 39 percent of the participants died.

Upon multivariate Cox regression analysis, Clinical Congestion Index, a composite of the aforementioned seven variables, emerged as a significantly predictive variable for death at baseline (hazard ratio [HR], 1.13, 95 percent CI, 1.04–1.22) and at 1 (HR, 1.17, 1.06–1.29), 3 (HR, 1.17, 1.05–1.31), 12 (HR, 1.14, 1.00–1.29) and 18 (HR, 1.25, 1.08–1.45) months.

Similarly, the Index was significantly correlated with death or hospitalization for heart failure at all time points: baseline (HR, 1.12, 1.05–1.20) and 1 (HR, 1.16, 1.07–1.26), 3 (HR, 1.23, 1.12–1.35), 6 (HR, 1.25, 1.13–1.39), 12 (HR, 1.20, 1.08–1.34) and 18 (HR, 1.35, 1.03–1.77) months.

“Intensification of therapy for heart failure resulted in significant reduction of congestion during the initial 6 months. However, congestion persisted or relapsed in a significant proportion of patients,” said researchers. “Still, it remains to be determined how to best achieve decongestion and if it is possible in all patients.”

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.