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09 Jan 2019
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CKD ups risk of mortality, complications in PAD patients on endovascular treatment

16 May 2018
Stem cells have been found to be responsible for calcification in arteries of patients with chronic kidney disease

Chronic kidney disease (CKD) in peripheral artery disease (PAD) patients who have received endovascular treatment (EVT) increases the risk of short-term mortality and unexpected amputation, a recent study has found.

The study included 3,434 patients with 5,794 limbs whose lower extremity artery disease was treated with EVT. Of these, 272 (9.9 percent; mean age 70.83±9.00 years; 85.3 percent male) had CKD while 2,467 (90.1 percent; mean age 68.47±9.48; 83.4 percent male) had no CKD.

Rates of in-hospital deaths were significantly higher in patients with CKD than those without (4.4 percent vs 1.2 percent; p<0.001), as were the rates of unexpected amputation (0.7 percent vs 0.0 percent; p=0.028).

Kaplan-Meier curves showed that patients without CKD also had significantly better overall survival (p<0.001) and major adverse limb event (MALE)-free survival (ie, major and minor amputations, lack of reintervention; p<0.001) than patients who developed CKD.

Multivariate Cox proportional hazard analysis showed that aside from the presence of CKD (hazard ratio [HR], 2.844; 95 percent CI, 2.026–3.990; p<0.001), age (HR, 1.068; 1.050–1.085; p<0.001) and stroke history (HR, 1.568; 1.143–2.152; p=0.005) were significantly correlated with mortality. CKD was also significantly associated with MALE (HR, 1.631; 1.265–2.103; p<0.001).

Notably, the severity of CKD had no apparent effect on in-hospital events, procedural complications, and overall and event-free survival rates.

“These findings provide additive evidence that the presence of CKD should be considered as an important worse clinical risk factor in the aspect of not only short-term death and unexpected amputation, but also long-term mortality and MALE-free survival,” said researchers.

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Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 5 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
5 days ago
Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids, a new study has shown. These patients tend to be older and have a more severe disease.