Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

CKD ups risk of mortality, complications in PAD patients on endovascular treatment

16 May 2018
Stem cells have been found to be responsible for calcification in arteries of patients with chronic kidney disease

Chronic kidney disease (CKD) in peripheral artery disease (PAD) patients who have received endovascular treatment (EVT) increases the risk of short-term mortality and unexpected amputation, a recent study has found.

The study included 3,434 patients with 5,794 limbs whose lower extremity artery disease was treated with EVT. Of these, 272 (9.9 percent; mean age 70.83±9.00 years; 85.3 percent male) had CKD while 2,467 (90.1 percent; mean age 68.47±9.48; 83.4 percent male) had no CKD.

Rates of in-hospital deaths were significantly higher in patients with CKD than those without (4.4 percent vs 1.2 percent; p<0.001), as were the rates of unexpected amputation (0.7 percent vs 0.0 percent; p=0.028).

Kaplan-Meier curves showed that patients without CKD also had significantly better overall survival (p<0.001) and major adverse limb event (MALE)-free survival (ie, major and minor amputations, lack of reintervention; p<0.001) than patients who developed CKD.

Multivariate Cox proportional hazard analysis showed that aside from the presence of CKD (hazard ratio [HR], 2.844; 95 percent CI, 2.026–3.990; p<0.001), age (HR, 1.068; 1.050–1.085; p<0.001) and stroke history (HR, 1.568; 1.143–2.152; p=0.005) were significantly correlated with mortality. CKD was also significantly associated with MALE (HR, 1.631; 1.265–2.103; p<0.001).

Notably, the severity of CKD had no apparent effect on in-hospital events, procedural complications, and overall and event-free survival rates.

“These findings provide additive evidence that the presence of CKD should be considered as an important worse clinical risk factor in the aspect of not only short-term death and unexpected amputation, but also long-term mortality and MALE-free survival,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.