Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Cirrhosis patients face increased fracture risk

06 Jul 2018

Patients with cirrhosis appear to have an elevated risk of fracture, according to a study, highlighting the importance of instituting preventive measures as early as possible.

Researchers performed a systematic review and meta-analysis of studies that examined the association between liver cirrhosis and fracture. They accessed several electronic databases for cohort or case–control studies and applied a random effects model in their analysis.

Pooled data from five cohort and three case–control studies, involving 321,035 cirrhotic individuals and 31,272 patients with fractures, showed that liver cirrhosis contributed to an increase in overall fracture risk (odds ratio [OR], 1.94; 95 percent CI, 1.59–2.37; I2=88.4 percent; p<0.001).

Increased fracture risk in patients with liver cirrhosis was also observed at the hip (OR, 2.11; 1.34–3.32), spine/trunk (OR, 2.00; 1.50–2.67) and limb (OR, 1.82; 1.65–2.01).

The underlying mechanism for the association between cirrhosis and fraction potentially involves osteoporosis, which is an important determinant for fracture. Cirrhotic patients are at risk of osteoporosis owing to hyperbilirubinaemia, corticosteroid use, physical inactivity, malnutrition, alcohol intake and impaired vitamin D absorption. [Eur J Gastroenterol Hepatol 2010;22:1397-1401]

Cognitive impairment, psychiatric illness and hepatic encephalopathy may also account for increased fracture risk in cirrhotic patients. [Osteoporos Int 2010;21:409-416; Am J Gastroenterol 2011;106:476-482]

Researchers warned that the findings should be interpreted in light of several study limitations. First, the original studies are observational in nature, and the results of which may be influenced by uncontrolled confounders and measurement errors. Second, the potential bias, confounding factors and heterogeneity among the original studies may also affect the results.

“However, care was taken to address these limitations by sensitivity analyses after excluding the largest sample size study and analysing the cohort studies and high-quality studies separately,” they said.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.