Most Read Articles
Yesterday
The appropriate cutoff value in predicting combined cardiovascular outcomes in patients with type 2 diabetes (T2D) is 125 mm Hg for home morning systolic blood pressure (MSBP), suggests a new study.
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.

Circulating tumour necrosis factors predict CVD in chronic kidney disease

19 Jul 2017

Circulating tumour necrosis factors (cTNFR) 1 and 2 are independent predictors of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD), a new study reveals.

Over a median follow-up of 3.4±2.0 years, 3.7 percent (n=36) of CKD patients (n=984; mean age 49.7±15.8 years; 56.1 percent male) developed CVD. Significantly more patients in the highest tertile of cTNFR1 and cTNFR2 levels had CVD compared to the lowest tertile (p<0.001).

Multivariate regression analysis showed that cTFNR1 and cTNFR2 levels were significant independent predictors of CVD (hazard ratio [HR], 2.506; 95 percent CI, 1.186 to 5.295; p=0.016; and HR, 4.156; 1.913 to 9.030; p<0.001, respectively) and end-stage renal disease (ESRD; HR, 5.927; 3.412 to 10.296; p<0.001; and HR, 3.297; 2.192 to 4.959; p<0.001, respectively).

On the other hand, only cTNFR2 levels were associated with all-cause mortality (HR, 7.448; 2.319 to 23.925; p=0.001). Models were fully-adjusted for sex, age, inflammation and other CVD factors.

A total of 19 deaths (1.9 percent) and 174 ESRD cases (17.7 percent) were recorded over the follow-up period.

The most common comorbidity among the participants was hypertension (53.6 percent; n=527) followed by diabetes (27.1 percent; n=267). The mean estimated glomerular filtration rate (eGFR) and high-sensitivity C-reactive protein (hs-CRP) level were 50.8±31.6 mL/min/1.73 m2 and 0.7±2.4 mg/dL, respectively.

Eligible study participants were divided into tertiles according to measured cTNFR1 and cTNFR2 levels. The primary endpoint of the study was occurrence of nonfatal myocardial infarction, stroke, revascularization or cardiovascular death. Patients with histories of heart failure or organ transplants were excluded.

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Most Read Articles
Yesterday
The appropriate cutoff value in predicting combined cardiovascular outcomes in patients with type 2 diabetes (T2D) is 125 mm Hg for home morning systolic blood pressure (MSBP), suggests a new study.
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.