Most Read Articles
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
19 Dec 2016
The prevalence of ECG for left ventricular hypertrophy (LVH) may vary depending on the criteria used across body mass index (BMI) categories in a low cardiovascular risk cohort, suggests a new study.
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.

Circulating tumour necrosis factors predict CVD in chronic kidney disease

19 Jul 2017

Circulating tumour necrosis factors (cTNFR) 1 and 2 are independent predictors of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD), a new study reveals.

Over a median follow-up of 3.4±2.0 years, 3.7 percent (n=36) of CKD patients (n=984; mean age 49.7±15.8 years; 56.1 percent male) developed CVD. Significantly more patients in the highest tertile of cTNFR1 and cTNFR2 levels had CVD compared to the lowest tertile (p<0.001).

Multivariate regression analysis showed that cTFNR1 and cTNFR2 levels were significant independent predictors of CVD (hazard ratio [HR], 2.506; 95 percent CI, 1.186 to 5.295; p=0.016; and HR, 4.156; 1.913 to 9.030; p<0.001, respectively) and end-stage renal disease (ESRD; HR, 5.927; 3.412 to 10.296; p<0.001; and HR, 3.297; 2.192 to 4.959; p<0.001, respectively).

On the other hand, only cTNFR2 levels were associated with all-cause mortality (HR, 7.448; 2.319 to 23.925; p=0.001). Models were fully-adjusted for sex, age, inflammation and other CVD factors.

A total of 19 deaths (1.9 percent) and 174 ESRD cases (17.7 percent) were recorded over the follow-up period.

The most common comorbidity among the participants was hypertension (53.6 percent; n=527) followed by diabetes (27.1 percent; n=267). The mean estimated glomerular filtration rate (eGFR) and high-sensitivity C-reactive protein (hs-CRP) level were 50.8±31.6 mL/min/1.73 m2 and 0.7±2.4 mg/dL, respectively.

Eligible study participants were divided into tertiles according to measured cTNFR1 and cTNFR2 levels. The primary endpoint of the study was occurrence of nonfatal myocardial infarction, stroke, revascularization or cardiovascular death. Patients with histories of heart failure or organ transplants were excluded.

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Most Read Articles
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
19 Dec 2016
The prevalence of ECG for left ventricular hypertrophy (LVH) may vary depending on the criteria used across body mass index (BMI) categories in a low cardiovascular risk cohort, suggests a new study.
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.