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3 days ago
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Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Cigarette smoking ups systemic lupus erythematosus risk

14 Oct 2020

Smoking cigarettes appears to increase the risk of systemic lupus erythematosus (SLE), suggests a recent study. In addition, sex and age do not contribute to the risk of SLE over time.

“The association between cigarette smoking and the risk of SLE remains a matter for debate,” the investigators said. “Additionally, the effect of the change of smokers’ demographics on the risk of development of SLE over time has not been formally addressed.”

A literature search was performed in computerized databases using the keywords ‘lupus’, ‘smoking’, ‘cigarette’, ‘environmental’, ‘autoimmune’, and ‘connective tissue disorder’ to identify studies examining the association between cigarette smoking and SLE occurrence.

A Bayesian meta-analysis was then conducted by computing the odds ratio (OR) between current and never smokers as well as former and never smokers. Multivariate meta-regression was used to assess the effect of publication time, sex, and age of patients with SLE on the effect sizes.

Twelve studies comprising 3,234 individuals with SLE and 288,336 control participants were identified. Data aggregation showed a significant association between current smoking status and SLE occurrence (OR, 1.54, 95 percent credible interval [CrI], 1.06–2.25) and a nonsignificant trend between former smoking status and SLE occurrence (OR, 1.39, 95 percent CrI, 0.95–2.08).

“Publication time, sex, and the mean age of patients with SLE did not explain the heterogeneity of the effect sizes,” the investigators said.

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Most Read Articles
3 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).