Most Read Articles
5 days ago
Diagnosis of heart diseases has abruptly and significantly decreased across the globe due to the coronavirus disease 2019 (COVID-19) pandemic, especially affecting poorer countries, reveals a study.
Pearl Toh, -19 hours ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.

Chronic viral infection a risk factor for idiopathic pulmonary fibrosis

19 Dec 2019

Persistent or chronic viral infections, such as Epstein-Barr virus (EBV) and cytomegalovirus (CMV), may promote the development, but not exacerbation, of idiopathic pulmonary fibrosis (IPF), according to the results of a meta-analysis.

Researchers searched multiple online databases for studies evaluating the effect of viral infection on IPF. They estimated statistical heterogeneity by using I2 and Cochran Q tests, as well as assessed publication bias using the funnel plot, Begg test, Egger test, and trim-and-fill methods. Regression, sensitivity and subgroup analyses were conducted to examine the effects of confounding factors, such as sex and age.

The meta-analysis included 20 case-control studies from 10 countries, with a total of 1,287 participants (mean age, 59.75 years; 69 percent male). All studies were deemed high-quality. There were 19 virus species detected using various laboratory examinations, including EBV, CMV, human herpesvirus (HHV)-6, HHV-7 and HHV-8.

Pooled data revealed that the odds of developing IPF were thrice as great in the presence of a viral infection (odds ratio [OR], 3.48, 95 percent confidence interval [CI], 1.61–7.52; p=0.001). This association was not observed for exacerbation of IPF (OR, 0.99, 95 percent CI, 0.46–2.12; p=0.988).

The findings validate the hypothesis implicating virus infection in the pathogenesis of IPF, the researchers said. Additional higher-quality studies with larger-scale samples are needed to draw conclusions about the exact causal relationship between the virus and IPF and/or the virus and acute exacerbation of IPF.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
Diagnosis of heart diseases has abruptly and significantly decreased across the globe due to the coronavirus disease 2019 (COVID-19) pandemic, especially affecting poorer countries, reveals a study.
Pearl Toh, -19 hours ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.