Most Read Articles
Audrey Abella, 16 Oct 2019
The PD-1* inhibitor nivolumab showed significant survival benefit and a favourable safety profile than taxane chemotherapy in patients with unresectable advanced or recurrent oesophageal squamous cell carcinoma (OSCC) refractory or intolerant to previous fluoropyrimidine- and platinum-based chemotherapy, according to the findings of ATTRACTION-3** presented at ESMO 2019.
03 Oct 2019
Early enteral nutrition (EEN) speeds up the recovery of gastrointestinal function after laparoscopic common bile duct exploration (LCBDE), according to a study. However, EEN also increases complications such as diarrhoea and abdominal distension.
01 Sep 2019
A third of Clostridium difficile infection (CDI) patients with cirrhosis have been readmitted in a span of 30 days primarily due to recurrent CDI, a recent study has found. In addition, there is a high rate of mortality linked to CDI in patients with cirrhosis, in which a poor prognosis is predicted by decompensation and 30-day readmission.
26 Sep 2019
Use of proton pump inhibitors contributes to increased risk of cholangitis, a large cohort study suggests.

Chronic liver disease tied to worse outcomes, higher complications in patients with fractures

18 Sep 2019

Mortality, length of stay (LOS) and hospital charges are significantly higher in chronic liver disease (CLD) patients with fractures, a recent study has shown. These findings are also associated with increased infection, bleeding and poorer wound healing.

Of the 931,193 patients who presented with orthopaedic fractures, 17,388 had CLD and 913,806 had no CLD (non-CLD). Those with CLD were almost twice as likely to succumb to death than non-CLD patients (odds ratio, 1.95, 95 percent CI, 1.8–2.1).

Patients with CLD vs non-CLD also had a longer mean LOS (7.4±8.6 vs 5.6±7.2 days; p<0.001) and higher total hospital charges ($76,198±99,494 vs $64,294±95,673; p<0.001). Moreover, rates of infections, bleeding and improper wound healing were higher among CLD patients.

“Increased clinician awareness of these risks is a key to improving the care of CLD patients,” the authors said.

This study obtained and analysed data from the National Inpatient Sample for the years 2012 to 2015. ICD-9 codes for any fracture were used to identify patients, while codes for CLD were used to categorize them into CLD and non-CLD groups.

Inpatients mortality, LOS and total hospital charges were the primary outcomes, while secondary outcomes were complications including postoperative infection, prosthetic failure, bleeding and improper wound healing.

“Cirrhotic patients are at a higher risk for sustaining orthopedic fractures with a reported prevalence of 5–20 percent,” the authors said. “Cirrhosis also affects wound healing and bleeding risk, and hence, impacts the postoperative outcomes after fracture repair.”

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Most Read Articles
Audrey Abella, 16 Oct 2019
The PD-1* inhibitor nivolumab showed significant survival benefit and a favourable safety profile than taxane chemotherapy in patients with unresectable advanced or recurrent oesophageal squamous cell carcinoma (OSCC) refractory or intolerant to previous fluoropyrimidine- and platinum-based chemotherapy, according to the findings of ATTRACTION-3** presented at ESMO 2019.
03 Oct 2019
Early enteral nutrition (EEN) speeds up the recovery of gastrointestinal function after laparoscopic common bile duct exploration (LCBDE), according to a study. However, EEN also increases complications such as diarrhoea and abdominal distension.
01 Sep 2019
A third of Clostridium difficile infection (CDI) patients with cirrhosis have been readmitted in a span of 30 days primarily due to recurrent CDI, a recent study has found. In addition, there is a high rate of mortality linked to CDI in patients with cirrhosis, in which a poor prognosis is predicted by decompensation and 30-day readmission.
26 Sep 2019
Use of proton pump inhibitors contributes to increased risk of cholangitis, a large cohort study suggests.