Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

3 days ago
Oestradiol therapy appears to protect certain types of cognition in the presence of stress, suggests a recent study.
17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.

Chronic iodine excess tied to hypothyroidism

16 Mar 2017

Chronic exposure to high levels of iodine, either in salt or in water, increases the risk of developing hypothyroidism, a new meta-analysis reveals.

PubMed, Ovid Medline and the Cochrane Central Register of Controlled Trials were accessed for the current meta-analysis. Observational studies and intervention trials that investigated the effects of excess iodine on thyroid diseases were included, whereas those that investigated unnatural sources of iodine (ie, medication and radiation) were excluded. The quality of the studies were assessed using the Cochrane Handbook for Systematic Reviews of Intervention.

After applying the inclusion and exclusion criteria, 50 studies were found eligible for inclusion. Of these, meta-analysis was only possible for the 35 cross-sectional studies and only for cases of subclinical hypothyroidism (SCH) in children, adults and pregnant women, and of overt hypothyroidism (OH) in adults.

Adult studies showed that the cases and the odds ratio (OR) of SCH were significantly greater in the group that received excess iodine than in those that received adequate levels. The corresponding ORs for SCH and OH were 2.03 (95 percent CI, 1.58 to 2.62) and 2.78 (1.47 to 5.27).

Studies in children and in pregnant women showed high levels of heterogeneity and thus did not yield reliable conclusions. Furthermore, there was only one study eligible for inclusion that investigated hyperthyroidism.

The number of included intervention trials, case-control and follow-up studies was too small, and this prevented integration of their results in the meta-analysis.

Overall, the present data highlight the lack of and need for high-quality studies investigating the relationship between iodine intake and thyroid diseases. 

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

3 days ago
Oestradiol therapy appears to protect certain types of cognition in the presence of stress, suggests a recent study.
17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.