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01 Dec 2019
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Chronic cough comorbidity increases disease severity in COPD

06 Feb 2020

Chronic obstructive pulmonary disease (COPD) patients with comorbid chronic cough appear to exhibit a more severe disease in terms of accompanying respiratory symptoms and healthcare utilization, lung function, and inflammation in blood, according to a study.

Researchers used data from a nested cohort of 43,271 adults from the Copenhagen General Population Study, among whom 8,181 (19 percent) had COPD with 796 (10 percent) of these having chronic cough.

Individuals with COPD and chronic cough comorbidity had a median total score on Leicester Cough Questionnaire of 17.7 (25th–75th percentiles, 16.0–18.9), which corresponded to 5.9 (5.3–6.3) for the physical domain, 5.6 (4.9–6.3) for the psychological domain, and 6.3 (5.8–6.8) for the social domain.

Among individuals with COPD, those with vs without chronic cough were more likely to have sputum production (60 percent vs 8 percent), wheezing (46 percent vs 14 percent), dyspnoea (66 percent vs 38 percent), chest pain/tightness (9 percent vs 4 percent), night-time dyspnoea (8 percent vs 3 percent), episodes of acute bronchitis/pneumonias in the last 10 years (45 percent vs 25 percent), and visits to a general practitioner in the past 12 months (53 percent vs 37 percent).

Furthermore, patients with the comorbidity had lower forced expiratory volume in 1 second (FEV1) percentage of predicted (81 percent vs 89 percent), FEV1/forced vital capacity (0.64 vs 0.66), as well as higher levels of inflammatory biomarkers in blood (eg, high-sensitive C-reactive protein, fibrinogen, leukocytes, neutrophils, eosinophils and IgE).

The present data suggest that chronic cough in individuals with COPD is associated with a more severe disease phenotype, which may aid in the management of COPD in the future, the researchers said.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.