Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
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Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
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Choline supplementation during pregnancy improves offspring information processing

09 Jan 2018

In pregnant mothers entering the third trimester, choline supplementation of approximately twice the recommended amount improves information processing in the offspring, a recent randomized, double-blind, controlled feeding study has shown.

Researchers randomized 26 women entering the third trimester of pregnancy to receive either 480 (n=13) or 930 (n=13) mg of choline supplements per day. Cognitive tests were performed on 24 offspring at ages 4, 7, 10, and 13 months.

In the adjusted regression analysis, the mean saccade reaction time (RT) of offspring of mothers who took the 930-mg choline supplements was 33.8 (95 percent CI, 2.7–54.9) ms faster than those of mothers who took the 480-mg supplements. The difference was statistically significant (p=0.03).

Age was also related with mean saccade RT, which declined significantly with increasing age (p<0.0001) in both treatment groups. Moreover, each additional week of gestation led to an 18.3-ms reduction in mean saccade RT.

To determine whether gestational age was a proxy for the duration of choline exposure, a new adjusted model was constructed, which showed a significant effect of days of exposure (p=0.02), but not gestational age (p=0.3), on RT. The resulting estimated effect of choline was 51.3 ms.

As expected, infants produced more predictive saccades for the predictable stimulus sequence than for the unpredictable baseline sequence (p<0.0001), but maternal choline intake had no significant impact (p=0.6).

“The results of this controlled-feeding trial reveal significantly faster saccade RT, a measure of information processing speed, among infants born to mothers consuming the higher level of choline intake throughout their third trimester,” said researchers.

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

4 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
4 days ago
Use of quetiapine among critically ill patients rarely leads to corrected QT (QTc) interval prolongation, reports a new study.