Most Read Articles
Stephen Padilla, 5 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.

Cholangitis, high bilirubin predict future need for liver transplant in adolescents with biliary atresia

17 Jun 2019

Cholangitis in adolescence and bilirubin levels 21 µmol/L at 16 years of age predict the future need for liver transplant (LT) in young people with biliary atresia, a new study has found.

Researchers performed a single-centre retrospective analysis of 89 patients who had undergone Kasai portoenterostomy and who had demonstrated native liver survival (NLS) until 16 years of age. Of the participants, 67 had NLS >16 years of age (group 1; median age, 16.0 years), while 22 required LT (group 2; median age, 16.1 years).

Kaplan-Meier analysis showed that 75 percent of the patients survived a mean of 6.9 years with their native liver. At 5 and 10 years after their respective 16th birthdays around 80 percent and 60 percent still had their native livers.

Both groups showed significant differences across most laboratory and radiological parameters tested. Bilirubin, for instance, was significantly higher in group 2 (38.5 vs 12 µmol/L; p<0.001), while the opposite was true for albumin (45 vs 37.5 g/L; p<0.001). Sodium was the only parameter comparable between groups (141 vs 140 mmol/L; p=0.117).

In comparison, at least one episode of cholangitis was reported significantly more frequently in group 2 vs 1 over the follow-up period (31.8 percent vs 3.03 percent; p=0.001).

Univariate Cox proportional hazard analysis showed that cholangitis increased the risk of LT >16 years by more than fourfold (hazard ratio [HR], 4.897, 95 percent CI, 1.973–12.158; p=0.001). The same was true for increased serum bilirubin (HR, 1.04, 1.026–1.054; p<0.001), while creatinine shared a significantly inverse correlation with LT >16 years (HR, 0.937, 0.901–0.974; p=0.001).

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Most Read Articles
Stephen Padilla, 5 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.