Most Read Articles
2 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, Yesterday
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Chlorpromazine–ketamine combo provides rapid relief of nausea, vomiting

07 Oct 2019

Use of the combination of chlorpromazine plus ketamine leads to rapid, definitive cessation of symptoms in patients presenting with intractable nausea and vomiting, as shown in a recent study.

The study population comprised 28 patients with unexplained nausea and vomiting. They presented with severe symptoms, such that median scores of pain and nausea were both 10. Most of the patients (n=23; 82 percent) reported using cannabis at least weekly, with 19 reporting daily use.

All patients were given slow intravenous infusion of ketamine 15 mg and chlorpromazine 12.5 mg over 15 minutes. Following treatment, the mean pain score decreased by 4.1 (95 percent CI, 3.2–5.0) over 120 minutes. Mean nausea score, on the other hand, dropped by 4.9 (4.0–5.8).

The treatment protocol was safe, and there were no adverse events recorded. All 28 patients were very satisfied with the medications, saying that they would want to receive them again.

The findings indicate that the combination of chlorpromazine plus ketamine may be used to treat nausea and vomiting without the need for opioids or benzodiazepines, researchers said.

A dopamine antagonist antiemetic, chlorpromazine was originally used to treat neurosis (sedation in psychiatric patients) and as preanaesthetic medication, inhibiting nausea, vomiting and shock. It also enhances the effects of anaesthetics and ketamine. [Front Pharmacol 2018;9:913]

Ketamine, on the other hand, is a nonopioid analgesic that has distinct sympathomimetic, vagolytic pharmacological properties. The substance is commonly used for analgesia and sedation. [Egypt J Anaesth 2012;28:169-174]

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Most Read Articles
2 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, Yesterday
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.