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CHD risk elevated in children conceived through IVF/ICSI

02 Dec 2017
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The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.

Researchers performed a systematic review and meta-analysis of studies comparing the neonatal incidence of CHD in spontaneous and IVF/ICSI conceptions. Those conceived through other types of assisted reproductive technologies were excluded. The databases of Scopus, PubMed and Embase were accessed for the study.

The meta-analysis included 41 observational studies corresponding to 25,856 IVF/ICSI and 287,995 spontaneously conceived children. In this cohort, the total rate of CHD events was 1.30 (n=337 of 25,658) and 0.68 (n=1,952 of 287,995) percent in the IVF/ICSI and spontaneous conception groups, respectively.

The risk of CHD was significantly higher in children conceived through IVF/ICSI than those spontaneously conceived (odds ratio [OR], 1.45; 95 percent CI, 1.20 to 1.76; p=0.0001).

Because of significant heterogeneity, subsequent sensitivity analyses were performed. When only the seven high-quality studies were analysed, the risk of CHD was still elevated in IVF/ICSI children, suggesting that the study quality did not affect the association (OR, 1.45; 1.19 to 1.77; p=0.0003).

When specific types of CHD were considered, the meta-analysis showed that all cardiac malformations were unrelated to mode of conception (OR, 1.13; 0.68 to 1.86; p=0.16). Moreover, while neither were significant, IVF/ICSI conception seemed to be more related to minor CHD (OR, 1.30; 0.66 to 2.56) than to major CHD (OR, 0.62; 0.16 to 2.39).

CHD risk was also significantly elevated in children from IVF/ICSI than from natural conception when the researchers considered only singleton pregnancies (OR, 1.55; 1.21 to 1.99) and after adjusting for parity and maternal age (OR, 1.29; 1.03 to 1.60).

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Most Read Articles
19 Dec 2016
The prevalence of ECG for left ventricular hypertrophy (LVH) may vary depending on the criteria used across body mass index (BMI) categories in a low cardiovascular risk cohort, suggests a new study.
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
Pearl Toh, 3 days ago
A higher dose of pitavastatin can benefit Japanese patients with stable coronary artery disease (CAD) compared with a low-dose pitavastatin, even though cardiovascular (CV) event incidence is known to be lower in Asian than Western patients, according to the REAL-CAD study presented at the AHA Scientific Sessions 2017.
01 Apr 2014
The basic life support (BLS) termination of resuscitation (TOR) rule recommends transport and continued resuscitation when cardiac arrest is witnessed by EMT-Ds, or there is a return of spontaneous circulation, or a shock is given.