Most Read Articles
6 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

4 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
6 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
2 days ago
Cabozantinib is not better than mitoxantrone-prednisone at relieving pain in patients with metastatic castration-resistant prostate cancer (mCRPC) with symptomatic bone metastasis, a recent study suggests.

Characterizing infectious keratitis in Asia

11 Sep 2018

In Asia, infectious keratitis occurs predominantly in males and is frequently associated with trauma, according to data from the Asia Cornea Society Infectious Keratitis study (ACSIKS). Visual acuity following infection may be poor, and corneal transplantation for active disease is associated with a high failure rate.

Researchers prospectively examined 6,626 eyes of 6,563 individuals (median age 46 years; 60.8 percent male) from countries including Japan, Philippines, Taiwan, Thailand, Singapore, India, China and South Korea. They obtained data on demographics, risk factors, microbiology and outcomes.

Overall, 2,521 eyes (38.0 percent) had bacterial keratitis and 2,166 eyes (32.7 percent) had fungal keratitis. The most frequently isolated microorganisms (n=2,831) included the Fusarium species (n=518; 18.3 percent), Pseudomonas aeruginosa (n=302; 10.7 percent) and Aspergillus flavus (n=236; 8.3 percent). Common risk factors for infection were trauma (n=2,279; 34.7 percent) and contact lens use (n=704; 10.7 percent).

Cornea transplantation was carried out in 628 eyes to manage active infection. At the end of the study, 289 grafts (46 percent) had failed. Visual acuity for each study eye was documented in 6,489 eyes, and more than half (53.6 percent) showed moderate visual impairment or worse (Snellen vision <20/60).

Researchers pointed out that the management of infectious keratitis was not standardized in ACSIKS, with medical and surgical treatment determined by the individual ophthalmologist based on their institutions’ practice. While this can be considered a limitation of our study, the finding also indicates that there is no single standard of care that can be applied throughout Asia.

Additionally, researchers acknowledged that they were not able to identify demographic, clinical or microbiological factors that may predispose patients to poor outcomes.

Nevertheless, the present data should serve as a baseline for describing and understanding corneal infections in Asia, guide ophthalmologists in the assessment and initial management of infectious keratitis, and ultimately contribute towards reducing corneal blindness in the region, researchers added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

4 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
6 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
2 days ago
Cabozantinib is not better than mitoxantrone-prednisone at relieving pain in patients with metastatic castration-resistant prostate cancer (mCRPC) with symptomatic bone metastasis, a recent study suggests.