Most Read Articles
2 days ago
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting. 
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Certain anti-inflammatory drugs exert beneficial effects in schizophrenia patients

23 Sep 2019

Several anti-inflammatory drugs, including aspirin, oestrogens, minocycline and N-acetylcysteine (NAC), appear to help mitigate symptom severity in patients with schizophrenia, according to a systematic review and meta-analysis.

Researchers searched multiple online databases for randomized controlled trials that explored concomitant use of anti-inflammatory agents in patients with a schizophrenia spectrum disorder (schizophrenia, schizophreniform disorder or schizoaffective disorder). None of the patients had schizotypal and schizoid personality disorder.

The meta-analysis included 56 studies reporting the effect of the following medications on symptom severity: aspirin, bexarotene, celecoxib, davunetide, dextromethorphan, oestrogens, fatty acids, melatonin, minocycline, NAC, pioglitazone, piracetam, pregnenolone, statins, varenicline and withania somnifera extract.

Pooled data revealed that some medications exerted significant beneficial effects on symptom severity, specifically aspirin (n=270; mean weighted effect size [ES], 0.30, 95 percent CI, 0.06–0.54), oestrogens (n=723; ES, 0.78, 0.36–1.19), minocycline (n=946; ES, 0.40, 0.11–0.68) and NAC (n=442; ES, 1.00, 0.60–1.41). In subgroup analysis, these drugs yielded greater positive effects in patients with first-episode psychosis or early-phase schizophrenia.

There were no beneficial effects observed with bexarotene, celecoxib, davunetide, dextromethorphan, fatty acids, pregnenolone, statins and varenicline.

Taken together, the present data support the immune hypothesis in schizophrenia, which suggests a possible treatment for patients in which the underlying pathophysiology is related to a subtle increase in the activation of microglia, according to the researchers. Despite the evidence, further studies are still needed.

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Most Read Articles
2 days ago
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting. 
Pearl Toh, 05 Aug 2020
The direct oral anticoagulant apixaban may help prevent deaths when given at prophylactic or therapeutic doses in hospitalized COVID-19 patients with elevated D-dimer levels, according to an analysis presented during the ISTH 2020 Congress.