Most Read Articles
Stephen Padilla, 25 Jul 2019
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Certain anti-inflammatory drugs exert beneficial effects in schizophrenia patients

23 Sep 2019

Several anti-inflammatory drugs, including aspirin, oestrogens, minocycline and N-acetylcysteine (NAC), appear to help mitigate symptom severity in patients with schizophrenia, according to a systematic review and meta-analysis.

Researchers searched multiple online databases for randomized controlled trials that explored concomitant use of anti-inflammatory agents in patients with a schizophrenia spectrum disorder (schizophrenia, schizophreniform disorder or schizoaffective disorder). None of the patients had schizotypal and schizoid personality disorder.

The meta-analysis included 56 studies reporting the effect of the following medications on symptom severity: aspirin, bexarotene, celecoxib, davunetide, dextromethorphan, oestrogens, fatty acids, melatonin, minocycline, NAC, pioglitazone, piracetam, pregnenolone, statins, varenicline and withania somnifera extract.

Pooled data revealed that some medications exerted significant beneficial effects on symptom severity, specifically aspirin (n=270; mean weighted effect size [ES], 0.30, 95 percent CI, 0.06–0.54), oestrogens (n=723; ES, 0.78, 0.36–1.19), minocycline (n=946; ES, 0.40, 0.11–0.68) and NAC (n=442; ES, 1.00, 0.60–1.41). In subgroup analysis, these drugs yielded greater positive effects in patients with first-episode psychosis or early-phase schizophrenia.

There were no beneficial effects observed with bexarotene, celecoxib, davunetide, dextromethorphan, fatty acids, pregnenolone, statins and varenicline.

Taken together, the present data support the immune hypothesis in schizophrenia, which suggests a possible treatment for patients in which the underlying pathophysiology is related to a subtle increase in the activation of microglia, according to the researchers. Despite the evidence, further studies are still needed.

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Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
6 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.