Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Cerebrospinal fluid markers may help assess neurodegeneration

27 Dec 2019
Many scientists believe that amyloids are key to the disease's effect on neurons

While cerebrospinal fluid (CSF) neurofilament light (NfL) levels indicate general and overall neurodegeneration, total tau (T-tau) and neurogranin (Ng) concentrations may be markers for neuronal response to amyloid pathology and neurodegeneration specific to Alzheimer’s disease (AD), a recent study has shown.

The study included 777 community-based adults (aged 50–95 years; 57.0 percent male) whose CSF samples were subjected to electrochemiluminescence and enzyme-linked immunosorbent assays for the measurement of NfL, Ng and T-tau levels.

Eighty-three (10.7 percent) participants were diagnosed with mild cognitive impairment (MCI), while seven (0.9 percent) had dementia. The median concentrations of NfL and T-tau levels increased with disease severity; no such effect was reported for Ng.

Multivariable analysis adjusted for covariates found that a diagnosis of MCI was associated only with elevated NfL levels, and not with high concentrations of T-tau or Ng. Stratifying by cognitive status, the correlations between cognition and each of the CSF markers were stronger in those with MCI or dementia.

Moreover, both gait speed and scores in the Charlson comorbidity index were more strongly associated with CSF T-tau and Ng in patients who were positive for amyloid pathology.

“As CSF NfL, T-tau and Ng move toward use in the clinic or for clinical trials as markers of disease progression and neurodegeneration, it is critical to better understand what these markers are measuring,” said researchers.

“Furthermore, with a move to clinical use, the development of reference ranges is needed,” they added.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.