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Stephen Padilla, 27 Jun 2019
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Central obesity linked to obstructive CAD in women with stable chest pain

28 Oct 2019

In postmenopausal women with stable chest pain undergoing invasive coronary angiography, central obesity may predict the development of obstructive coronary artery disease (CAD), according to a study.

Researchers used data from a nationwide registry including 659 women with chest pain aged >55 years. All women were undergoing elective invasive coronary angiography in the suspicion of CAD.

A total of 311 women (47.2 percent) developed obstructive CAD, which was defined as angiographic findings of ≥50 percent diameter stenosis with any major epicardial coronary artery.

The number of those with overall obesity (body mass index [BMI] ≥25 kg/m2) did not significantly differ between women with and without obstructive CAD (p=0.340). On the other hand, obstructive CAD was detected more frequently in women with vs without central obesity (waist circumference of ≥85 cm; 55.5 percent vs 41.0 percent; p<0.001). Body mass index was similar in women with and without obstructive CAD (p=0.373).

On multivariable analysis, central obesity was associated with a greater likelihood of obstructive CAD (odds ratio, 1.61, 95 percent CI, 1.10–2.34; p=0.013). This was not true for overall obesity (p=0.228).

The present data show that relative to overall obesity, central obesity is a better predictor of obstructive CAD in women with stable chest pain, according to the researchers.

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Most Read Articles
Stephen Padilla, 27 Jun 2019
Accelerated cognitive decline is significantly associated with incident coronary heart disease (CHD) after, but not before or immediately following, ischaemic events, suggests a recent study.
12 Jan 2020
Levels of high-sensitivity C-reactive protein (hs-CRP) in the serum are predictive of more severe coronary artery disease (CAD), reports a recent study.
6 days ago
Bicuspid and tricuspid aortic valve patients have comparable 30-day and 1-year mortality outcomes after transcatheter aortic valve replacement (TAVR), reports a recent meta-analysis. Rates of stroke and new pacemaker implants are likewise similar.
Christina Lau, 02 Jan 2020

A left ventricular ejection fraction (LVEF) cut-off of 60 percent may identify patients with heart failure (HF) with mid-range or preserved ejection fraction (mrEF or pEF) who could benefit from drug therapy.