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Pearl Toh, 12 Sep 2020
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Central obesity linked to obstructive CAD in women with stable chest pain

28 Oct 2019

In postmenopausal women with stable chest pain undergoing invasive coronary angiography, central obesity may predict the development of obstructive coronary artery disease (CAD), according to a study.

Researchers used data from a nationwide registry including 659 women with chest pain aged >55 years. All women were undergoing elective invasive coronary angiography in the suspicion of CAD.

A total of 311 women (47.2 percent) developed obstructive CAD, which was defined as angiographic findings of ≥50 percent diameter stenosis with any major epicardial coronary artery.

The number of those with overall obesity (body mass index [BMI] ≥25 kg/m2) did not significantly differ between women with and without obstructive CAD (p=0.340). On the other hand, obstructive CAD was detected more frequently in women with vs without central obesity (waist circumference of ≥85 cm; 55.5 percent vs 41.0 percent; p<0.001). Body mass index was similar in women with and without obstructive CAD (p=0.373).

On multivariable analysis, central obesity was associated with a greater likelihood of obstructive CAD (odds ratio, 1.61, 95 percent CI, 1.10–2.34; p=0.013). This was not true for overall obesity (p=0.228).

The present data show that relative to overall obesity, central obesity is a better predictor of obstructive CAD in women with stable chest pain, according to the researchers.

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Most Read Articles
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.