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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 19 hours ago
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Central obesity bears risk of breast cancer

09 Jan 2021

Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.

The study used prospective waist (WC) and hip circumference (HC) data in the Nurses’ Health Studies. These measures, along with waist-to-hip ratio (WHR), were analysed in relation to breast cancer incidence independent of body mass index (BMI).

BMI-adjusted multivariable Cox proportional hazards models revealed that WC and HC were not associated with premenopausal breast cancer risk. On the other hand, WHR conferred a risk increase, such that women in the highest WHR quintile had a 27-percent higher risk compared with those in the lowest quintile (hazard ratio [HR], 1.27, 95 percent confidence interval [CI], 1.04–1.54; p=0.01). This association was particularly evident for oestrogen receptor-negative (ER-)/progesterone receptor-negative (PR-) and basal-like breast cancers.

Premenopausal WC, HC, and WHR showed no association with postmenopausal breast cancer risk, with or without controlling for BMI.

Meanwhile, postmenopausal WC, HC, and WHR were all positively associated with postmenopausal breast cancer. But after adjusting for BMI, the association remained significant for only WC (quintile 5 vs 1: HR, 1.38, 95 percent CI, 1.15–1.64; p=0.002). The estimates were greater among never users of hormone therapy and for ER+/PR+ breast cancers.

The findings suggest that mechanisms other than oestrogen may play a role in the relationship between central adiposity and breast cancer. The risk may then be mitigated by maintaining a healthy WC.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 19 hours ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.