Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
For inflammatory bowel disease (IBD) patients, smoking cigarettes or just being exposed to secondhand smoke raises the risk of developing colorectal neoplasia, a study has found.
Jairia Dela Cruz, Yesterday
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Cell therapy with autologous DSC may help treat hair loss

06 Jul 2020

Autologous cell-based therapy using dermal sheath cup (DSC) appears to have beneficial effects for the treatment of male (MPHL) and female pattern hair loss (FPHL), suggest the results of a study.

The investigators assessed the safety and efficacy of cell-based therapy with autologous DSC to treat MPHL and FPHL. DSH cells were manufactured by culturing DSCs dissected from occipital hair follicles. Fifty men and 15 women (aged 33–64 years) with hair loss received single injections of 7.5 × 10 6, 1.5 × 10 6, or 3.0 × 10 5 DSC cells or a placebo in four randomized separate regions on the scalp. The investigators then measured hair densities and diameters at 3, 6, 9, and 12 months.

Compared with placebo, single injections of 3.0 × 10 5 DSC cells led to a significant increase in total hair density and cumulative hair diameter after 6 and 9 months. Improvements were similarly observed in men and women. In addition, no serious adverse events were recorded.

This study certain limitations. First, no lower cell numbers were tested. Second, the positive effect observed was temporary until 9 months, according to the authors.

The 2017 guidelines for the diagnosis and treatment of MPHL and FPHL suggest the use of finasteride 1 mg daily, dutasteride 0.5 mg daily, and topical 5% minoxidil twice daily for MPHL, and topical 1% minoxidil twice daily for FPHL as first-line treatments, while self-hair transplantation, irradiation by light-emitting diodes and low-level lasers, and topical application of adenosine are recommended for MPHL. However, prosthetic hair transplantation and oral administration of minoxidil are discouraged. [J Dermatol 2018;45:1031-1043]

Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
For inflammatory bowel disease (IBD) patients, smoking cigarettes or just being exposed to secondhand smoke raises the risk of developing colorectal neoplasia, a study has found.
Jairia Dela Cruz, Yesterday
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.