Most Read Articles
11 Apr 2019
Cannabis use disorder appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.
10 Apr 2019
An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease, successfully replicating microbiome changes elicited by exclusive enteral nutrition and reducing gut inflammation, a recent study has shown.
12 Nov 2018
Individuals with severe and frequent gastro-oesophageal reflux disease (GERD) are at increased risk of Barrett’s oesophagus (BE), especially in the absence of frequent proton pump inhibitor (PPI) use, a recent study has found. Family history of BE and early age of symptom onset are strong predictors of BE among people with GERD.

Celecoxib use may induce liver injury

27 Jan 2018

There is an over-representation of women in published reports of celecoxib drug-induced liver injury (DILI), according to a recent study. Latency has been shown to be short (<3 months) in most patients, but some of them may present with DILI after prolonged use of celecoxib.

“Although rare, celecoxib DILI can have potentially life-threatening consequences,” researchers said.

Eighteen patients (median age 54 years; range, 29‒84; 88 percent female) presented with celecoxib DILI. The median daily dose was 200 mg (range, 200‒533), and median duration and latency were 13 days (1‒730) and 17 days (2‒730), respectively.

DILI was reported in 15 patients (83 percent) after relatively short treatment duration (median 12 days; 1‒42). These patients presented with rash and immunoallergic features, with peripheral or histologic findings of eosinophilia in six (40 percent). In three patients, DILI occurred following prolonged use of celecoxib (range, 152‒730 days), with no immunoallergic features observed.

Liver injury included the following: hepatocellular (n=6), mixed (n=5) and cholestatic (n=4); three patients had an unknown pattern. Clinical outcomes included liver transplantation in two patients (11 percent), chronic liver injury in four (22 percent) and recovery in 12 (67 percent).

Researchers performed a literature search from 2000‒2016 using common terms for liver injury cross-referenced with celecoxib to characterize and examine the salient features of published cases of celecoxib DILI. They analysed identified cases with respect to reported demographic and clinical data.

A commonly prescribed nonsteroidal anti-inflammatory drug, celecoxib has been associated with rare instances of idiosyncratic DILI, according to researchers.

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Most Read Articles
11 Apr 2019
Cannabis use disorder appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.
10 Apr 2019
An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease, successfully replicating microbiome changes elicited by exclusive enteral nutrition and reducing gut inflammation, a recent study has shown.
12 Nov 2018
Individuals with severe and frequent gastro-oesophageal reflux disease (GERD) are at increased risk of Barrett’s oesophagus (BE), especially in the absence of frequent proton pump inhibitor (PPI) use, a recent study has found. Family history of BE and early age of symptom onset are strong predictors of BE among people with GERD.