Most Read Articles
01 Jun 2016
Adapalene 0.3%/benzoyl peroxide 2.5% topical gel is a safe and effective treatment option in patients with moderate and severe inflammatory non-nodulocystic acne, based on a multicentre, randomised, double-blind, parallel-group study.
06 Jun 2016

The recent Paediatrics in Practice (PIP) 2016 held recently in Selangor was a success. On top of the launch of a locally published atlas, the conference also featured the introduction of DEBRA (Dystrophic Epidermolysis Bullosa Research Association), various presentations, a workshop and panel discussion on paediatric skin diseases by prominent specialists such as Dr. Tang Jyh Jong, Dr. Tan Wooi Chiang, Dr. Chan Lee Chin, Dr. Sabeera Begum and Dr. Leong Kin Fon. MIMS Doctor spoke to Dr. Thiyagar Nadarajaw, paediatrician and adolescent medicine specialist and Leong, a consultant paediatric dermatologist at the Kuala Lumpur Hospital about the PIP workshop and their thoughts on the atlas.

26 May 2016
Melasma is a benign pigmentary skin disorder. However, it features prominently on sun-exposed areas, typically the face and arms, and as such affects the quality of life of those with the disorder. Radha Chitale spoke with Dr. Gavin Ong Chun Wei, a dermatologist at The Skin Specialist clinic in Singapore, about how GPs can best diagnose and treat patients with melasma.
4 days ago
There appears to be an association between hand eczema and the risk of food allergy among occupational kitchen workers, a study reports.

CDKN2A mutation status, family history of melanoma tied to worse outcomes in MPM patients

13 Nov 2017

Family history of melanoma and CDKN2A mutation status significantly affect the risks of developing subsequent melanomas and other cancers and survival outcomes in patients with multiple primary melanomas (MPMs), a recent study has shown.

To determine how family history of melanoma and germline CDKN2A mutation status affected outcomes of MPM patients, researchers retrieved comprehensive data on cancer diagnoses and deaths of MPM patients, their first-degree relatives and matched controls from Swedish national healthcare and population registries.

Familial cases of MPM with germline CDKN2A mutations were youngest at the diagnosis of their second melanoma (median age 42 years) and had the highest relative risks (RR) of developing >2 melanomas (RR, 238.4; 95 percent CI, 74.8 to 759.9) among the MPM cohorts compared with controls.

Compared to controls, only those with CDKN2A-mutated MPM cases (RR, 3.6; 1.9 to 147.1) and their first-degree relatives (RR, 3.2; 1.9 to 5.6) had elevated risks of nonskin cancers. Moreover, survival was worse in CDKN2A-mutated MPM cases compared with both cases with familial (hazard ratio [HR], 3.0; 1.3 to 8.1) and sporadic wild-type MPM (HR, 2.63; 1.3 to 5.4).

“Our study examined outcomes in subgroups of MPM patients, which affected the sample size of the study groups,” researchers noted.

In a separate study, the same researchers concluded that CDKN2A-mutated cases had significantly worse survival than nonskin cancers and from melanoma compared with melanoma cases without CDKN2A mutations. [J Natl Cancer Inst 2016;doi:10.1093/jnci/djw135]

“Further studies are required to elucidate possible mechanisms behind increased carcinogen susceptibility and the more aggressive melanoma phenotype in CDKN2A mutation carriers,” they added.

Editor's Recommendations
Most Read Articles
01 Jun 2016
Adapalene 0.3%/benzoyl peroxide 2.5% topical gel is a safe and effective treatment option in patients with moderate and severe inflammatory non-nodulocystic acne, based on a multicentre, randomised, double-blind, parallel-group study.
06 Jun 2016

The recent Paediatrics in Practice (PIP) 2016 held recently in Selangor was a success. On top of the launch of a locally published atlas, the conference also featured the introduction of DEBRA (Dystrophic Epidermolysis Bullosa Research Association), various presentations, a workshop and panel discussion on paediatric skin diseases by prominent specialists such as Dr. Tang Jyh Jong, Dr. Tan Wooi Chiang, Dr. Chan Lee Chin, Dr. Sabeera Begum and Dr. Leong Kin Fon. MIMS Doctor spoke to Dr. Thiyagar Nadarajaw, paediatrician and adolescent medicine specialist and Leong, a consultant paediatric dermatologist at the Kuala Lumpur Hospital about the PIP workshop and their thoughts on the atlas.

26 May 2016
Melasma is a benign pigmentary skin disorder. However, it features prominently on sun-exposed areas, typically the face and arms, and as such affects the quality of life of those with the disorder. Radha Chitale spoke with Dr. Gavin Ong Chun Wei, a dermatologist at The Skin Specialist clinic in Singapore, about how GPs can best diagnose and treat patients with melasma.
4 days ago
There appears to be an association between hand eczema and the risk of food allergy among occupational kitchen workers, a study reports.