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Catheter ablation boosts QoL, exercise tolerance among patients with persistent AF

25 Apr 2020

Catheter ablation improves exercise tolerance and quality of life (QoL) among patients with persistent atrial fibrillation (per-AF), a recent study has found.

Fifty-three per-AF patients (mean age, 65.6±8.7 years; 77 percent male) who underwent catheter ablation were enrolled. QoL was set as the primary endpoint of the study and was assessed using an original tool, along with functional evaluation, at 3 months after the procedure. A symptom-limited cardiopulmonary exercise test was administered at baseline and at 3 months after ablation.

Overall, QoL increased significantly from 5.48±1.14 at baseline to 5.64±1.06 after 3 months (p=0.010). This was driven mainly by a statistical increase in scores in those who reported symptom improvements in daily life (5.32±0.94 to 5.7±0.94; p=0.010). The change in QoL scores was null in participants who reported no such improvements.

Notably, all measures in the cardiopulmonary exercise test improved significantly after ablation. At the 3-month follow-up, peak work rate increased from 84.6±24.3 to 96.2±24.0 watts (p<0.001). The same was true for anaerobic threshold (13.1±3.0 to 15.1±3.3 mL/kg/min; p<0.001) and peak oxygen consumption (19.1±4.6 to 22.5±5.0 mL/kg/min; p<0.001).

The maximum heart rate, on the other hand, dropped from 156.6±26.0 to 126.9±20.8 beats per minute (p<0.001). These effects were sustained and remained significant even in the subgroups of patients with and without daily symptom improvements.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.